Mood disorders Flashcards
overall state of emotion at a given time
Internal condition visible through external behaviors
mood
mood is influenced by ? factors
internal and external
Mood is regulated by what neurotransmitters in the brain?
Serotonin
Norepinephrine
Dopamine
what are the types of mood disorders
- Depressive Disorders
- Bipolar Disorders
5 types of depressive disorders
- Major Depressive Disorder
- Dysthymia/Persistent Depressive Disorder
- Seasonal Affective Disorder
- Premenstrual Dysphoric Disorder (PMDD)
- Disruptive Mood Dysregulation Disorder
3 types of bipolar disorders
- Bipolar I Disorder
- Bipolar II Disorder
- Cyclothymia
For ALL PSYCHIATRIC CONDITIONS, the DSM endorses a criteria-based diagnostic approach that requires 3 conditions:
- The condition is not caused by the direct effects of any drug or external exposure
- The psychiatric disorder is not caused by effects of a medical condition
- There is significant impairment of social functioning, occupational functioning, or both.
MDD is MC in who?
- younger populations
- women (2-3x)
- Native Americans
- low socioeconomic status
MDD - Etiology / Risk Factors
- Genetics/Biological
- Neurotransmitter expression / sensitivity - Serotonin, norepinephrine, glutamate, GABA, dopamine
- Response to antidepressant drugs
- FH of depression or alcoholism - Life Events
- Adversity or loss of loved one, job, or relationship
- Early childhood trauma
- Postpartum period - Medications
- Glucocorticoids, Interferons - Personality
- Low self-esteem
- Sensitive to stressors
- Insecure or worried
- Dependent or unassertive
- Introverted - Social
- Lack of close relationships
- Close individuals with depression
- Maladaptive learned behaviors from close individuals - Medical Conditions
- Neurologic, Infectious, Cardiac, Endocrine (adrenal/thyroid), Cancer, Inflammatory
How does the DSM-5 diagnose MDD
A depressed mood or anhedonia for ≥ 2 weeks AND ≥ 4 of the following symptoms:
1. Sleep changes (hypersomnia or insomnia)
2. Feelings of worthlessness / guilt
3. Fatigue / ↓energy
4. ↓concentration
5. Significant appetite or weight change
6. Activity changes (psychomotor agitation or retardation)
7. Recurrent thoughts about death or suicide
(SIG E CAPS)
8 MDD episode subtypes
- Anxiety: high levels of accompanying anxiety
- Catatonic: major psychomotor disturbances
- Mixed: symptoms of mania (insomnia, racing thoughts, ↑ energy)
- Psychotic: with accompanying psychosis (hallucinations, delusions)
- Atypical: reactivity to pleasurable stimuli, hyperphagia, hypersomnia
- Melancholic: anhedonia, psychomotor changes, insomnia, ↓appetite
- Peripartum: during pregnancy or within 4 weeks of birth
- Seasonal: associated with a particular season
To have MDD, a patient has to have at least one ?
major depressive episode
describe the timelines of major depressive episodes (developing, resolution, reoccurence)
- develops over days to weeks
- avg time to resolution - 20 wks
- highest risk of recurrence - within first few months following episode’s resolution
how do the course of MDD varies?
- Single major depressive episode that resolves
- Multiple episodes with few to no s/s between episodes
- Persistent, fluctuating depressive s/s with no clear “remission”
high rate of recurrence is during when?
lifetime
what are other differentials for MDD
- Other mood disorders
- Substance use/abuse - alcohol, amphetamines
- Medication side effects
- General medical disorders
- grief symptoms associated with ___
3 MDD screenings
- Two-Question Screen (PHQ-2)
- Quick, initial screening for depression
- Asks about the two key symptoms of a depressive episode (depressed mood and anhedonia)
- Not a stand-alone test - needs follow-up if positive! - Patient Health Questionnaire-9 (PHQ-9)
- Further evaluates presence and severity of depression
- Can be used for initial screening or follow-up evaluation - Zung Self-Rated Depression Scale
- Allows a more in-depth rating of current depressive symptoms
nonpharm management for MDD
- Psychotherapy
- Electroconvulsive Therapy (ECT)
- Vagal Nerve Stimulation
- Transcranial Magnetic Stimulation (TMS)
tx goals for MDD
- Provide thorough education
- Maintain patient safety
- Achieve full remission of symptoms
- Achieving remission lowers risk of relapse
- Return patient to baseline functioning
what is the preferred approach of MDD tx
- COMBINATION of pharmacotherapy AND psychotherapy
- It is acceptable to use either option by itself
- MC approach - pharmacotherapy only
what type of tx would a pt get if they present with:
- No suicidal/homicidal ideation or behavior
- No psychotic features
- Minimal to no aggressiveness
- Intact judgement
- Able to perform basic ADL and maintain adequate nutritional/hydration status
outpatient tx
what type of tx would a pt get if they present with:
- Suicidal/homicidal ideation or behavior with specific plan or intent
- Psychosis
- Catatonia
- Impaired judgement that puts patient/others at risk for harm
- Grossly impaired functioning affecting ability to care for self
inpatient tx
- aka “counseling”
- CBT or Interpersonal Psychotherapy are most commonly used
- Family or couples therapy can also be useful
psychotherapy
Meditation, muscle relaxation
are what types of nonpharm tx?
Relaxation Techniques
Restarting positive activities that ceased due to depression
is what type of nonpharm tx?
Behavioral Activation
Use of a small electric current to induce a cerebral seizure while patient is under general anesthesia
Electroconvulsive Therapy (ECT)
indications for Electroconvulsive Therapy (ECT)
- MC for severe, refractory depression
- 1st Line: severe suicidality, severe psychosis, catatonia, malnutrition d/t food refusal secondary to depressive illness
- Cannot tolerate other therapies
what is the most efficacious tx for severe MDD
Electroconvulsive Therapy (ECT)
be cautious with ECT in pts with ?
- cardiopulmonary disease
- neurologic disease
- anticoagulants
no absolute CIs
SE of ECT
- Overall, considered safe
- MC adverse events:
- cardiopulmonary
- HA
- nausea
- transient cognitive impairment
- muscle aches
A device is implanted in the chest wall
Used primarily for refractory epilepsy
Vagal Nerve Stimulation - connected to one (left) vagus nerve
May be helpful for refractory depression
Metal coil with magnetic field is placed against scalp to induce depolarization of neurons in a focal area WITHOUT sedation/anesthesia
Transcranial Magnetic Stimulation (TMS)
indications for Transcranial Magnetic Stimulation (TMS)
Treatment-refractory depression
CI for Transcranial Magnetic Stimulation (TMS)
- High seizure risk
- incompatible implants (metallic, electrical, cochlear)
SE of Transcranial Magnetic Stimulation (TMS)
- Seizures
- HA
- scalp pain
- transient hearing loss
what supplement:
- Naturally occurs in the body; may raise dopamine levels
- Can be used as an adjunctive option for mild to moderate depression in pregnant patients
- May trigger manic episodes
S-Adenosylmethionine (SAMe)
what supplement:
- Natural precursor to serotonin
- Risk of GI upset, serotonin syndrome, eosinophilic myalgia syndrome
5-Hydroxytryptophan (5-HTP)
what supplement:
- May work better if combined with antidepressants
- May increase risk of bleeding
Omega-3 Fatty Acids
what herbal:
- Increases serotonin, and possibly norepinephrine and dopamine levels
- Risk of GI upset, serotonin syndrome, photosensitivity
- Numerous drug-drug interactions (DDIs)
st. john’s wort
what herbal:
- May help with depression; MOA unclear
- Risk of GI upset, mania, bleeding; can be fatal at high doses
saffron
what herbal:
- Improved mood in pts being treated for memory loss; may increase sensitivity to serotonin
- May increase risk of bleeding
Ginkgo biloba
what supplements could be used as tx for MDD
- S-Adenosylmethionine (SAMe)
- 5-Hydroxytryptophan (5-HTP)
- Omega-3 Fatty Acids
what herbals could be used as tx for MDD
- st. john’s wort
- saffron
- ginkgo biloba
what are the guidelines for antidepressant use?
- Start low and go slow
-
Trial of at least 4 weeks to evaluate full benefit
- may see improvement as early as week 1, but it generally takes 4-6 weeks to see a response - Rx should be continued for 6+ months after s/s improvement
- Gradual down titration is recommended when discontinuing antidepressants
what are the 1st gen antidepressants
- MAOI
- TCA
- TeCA
what are the 2nd gen antidepressants
- SSRI
- SNRI
- atypical antidepressants
- serotonin modulators
- ketamine/esketamine
- Commonly used as 1st line treatment for MDD
- Selectively decreases the action of 5-HT reuptake pump, leading to increased serotonin levels in the synapse
SSRIs
Sertraline (Zoloft)
SSRI
Citalopram (Celexa)
SSRI
Escitalopram (Lexapro)
SSRI
Fluoxetine (Prozac)
SSRI
Paroxetine (Paxil)
SSRI
Fluvoxamine (Luvox)
SSRI
Use caution in ____ with SSRIs
hepatic impairment
(metabolized mostly by the liver)
CI for SSRI
Allergy to SSRI; use of MAOI within 2 weeks
which SSRI must wait 5 weeks before starting MAOI
Fluoxetine
SE of SSRI
- GI Upset
- nausea
- diarrhea
- anorexia - Sleep Change
- insomnia
- hypersomnia - Neuro
- HA
- dizziness - Sexual Dysfunction
- ↓libido
- anorgasmia
- ED - Psych:
- anxiety
- ↑ risk of suicide (MC young adults) - Other:
- prolonged QT
- weight gain
- bleeding
- orthostatic hypotension
- serotonin syndrome
what is serotonin syndrome? when does it happen?
- Caused by increased serotonergic activity
- Typically occurs within 24 hrs (often w/n 6 hrs) of starting/changing medication or overdosing
serotonin syndrome is MC associated with what specific medication?
SSRI
s/s of serotonin syndrome
Diarrhea
increased bowel sounds
agitation
hyperreflexia
dry mucous membranes
autonomic instability
hyperthermia
HTN
tremor
clonus
seizure
death
tx for serotonin syndrome
- Supportive care
- D/C serotonergic medications
- Sedation with benzodiazepines
- Normalize vitals and hydration status
which SSRI:
- More GI upset than others in the class, esp. diarrhea
- Less likely to cause prolonged QT, drowsiness
- Slightly higher chance of insomnia SE
Sertraline (Zoloft)
which SSRI:
- Most associated with prolonged QT
- Minimal SE profile for this class otherwise
- Least inhibition of hepatic cytochrome enzymes
Citalopram (Celexa) / Escitalopram (Lexapro)
- Escitalopram is an isomer of citalopram