sub-gingival plaque -> the pathogens Flashcards
rapidly progressing bacteria is linked to what pathogen?
Aggregatibacter actinomycetemcomitans
where is agggregatibactor actinomycetemcomitans found?
Found in gingival sulcus and periodontal pocket
is aggregatibacter actinomycetemcomitans gram +ve or -ve?
Gram -ve
what virulence factors does aggregatibacter actinomycetemcomitans have?
leukotoxin
lipopolysaccharides
outer membrane vesicles
what does the virulence factor leukotoxin do?
kills PMNs (leukocytes) and monocytes or induces T cell apoptosis
what does the virulence factor lipopolysaccharides do?
Cause osteoclast activation -> bone destruction
what do the virulence factor outer membrane vesicles do?
Bind to receptors on cells, stimulates the release of acute phase cytokines (inflammation)
where is porphyromonas found and which complex is it?
red complex
Found exclusively in the gingival sulcus and periodontal pocket
what does porphyromonas cause?
periodontitis and bone destruction
what colour is porphyromonas in culture on petri dish?
Dark purple as iron scavenging due to needing an external iron source
black pigmented
porphyromonas produce proteases that destroys cells to get energy from amino acids and peptides. what is this called?
asaccharolytic
what virulence factors does porphyromonas produce?
gingipains to avoid host immune system
other than periodontitis what other disease is porphyromonas linked to?
alzheimer’s
what complex is tanerella forsythia?
red complex
what does tanerella forsythia cause?
periodontitis, gingivitis, endodontic infections
what are tanerella forsythia’s virulence factors?
Fibrinogen binding BspA
For adhesion, invasion, induces release of bone reabsorbing cytokines, induces chemokines
what complex is fusobacterium nucleatum?
orange complex
fusobacterium is linked to what?
periodontitis and diversification of plaque
what virulence factors do fusobacterium nucleatum produce?
Virulence factor FadA which is involved in extra-oral infections
other than periodontitis what disease is fusobacterium nucleatum linked to?
colorectal cancer
