stuff

Question 1

Disulfiram

Answer 1

• Forms a covalent bond with acetaldehyde dehydrogenase which prevents the formation of actin acid

Question 2

Melphalan

Answer 2

• Looks like amino acid but it carries mustard gas reactive part, not specific
• Targets cancer bc cancer cells quickly proliferate which means they need more amino acids
• Hence, used to treat cancer

Question 3

Aspirin

Answer 3

• Carboxylic acid in aspirin binds to a part of COX which brings the ester into close proximity of the OH in COX and leads to the formation of covalent bond

Question 4

Why is mustard gas so dangerous?

Answer 4

• Due to intramolecular rxn which makes it extremely reactive
• If nitrogen changed to a carbon, it would be less reactive / wouldn’t do intramolecular rxns

Question 5

Covalent Functionality

Answer 5

Typically the reactive part is an unsaturated ketone or epoxide