Fergie Flashcards
1
Q
Examples of targeted protein degradation in the clinic
A
- Molecular Glues: Thalidomide, Pomalidomide, Lenalidomide
- PROTACs: ARV-110
2
Q
How do protein degraders work?
A
Targeted protein degraders hijack the ubiquitin proteasome system to trigger degradation of their targets.
3
Q
Anatomy of a bivalent degrader (slide 8)
A
Linker, E3 recruiter, and targeting ligand
4
Q
What is a protein degrader?
A
A small molecule that induces the selective proteolysis of a targeted protein
