Siegel, again

Question 1

Tetracycline

Answer 1

• Antibiotic produced by fermentation

- Inhibits protein biosynthesis by ribosomal binding and possess broad spectrum antibiotic activity

Question 2

What are the market challenges in developing new antibiotics?

Answer 2

• Side effects (vomiting, diarrhea, rash, loss of appetite, yellowing teeth, sunburn easily)
• Resistance (efflux pumps, horizontal gene transfer)
• 6 cents to $4.06, more expensive now
• Hard in terms of commercialization bc the target market + regulations make it difficult

Question 3

How was exposure in the IV to oral dosing of eravacycline increased?

Answer 3

IV to oral

• Increased interval between meals and dosing (250 mg ER) can achieve 81% of concentration possible with IV
• Doubled the exposure in IGNITE II