Saghatelian Flashcards
1
Q
Advantages and Disadvantages of Small Molecules
A
A - Represent most drugs
A - Often cell permeable
D - From a known pathway to drug is a long road
D - Can address only a subset of targets
2
Q
Advantages and Disadvantages of Biologics/Macromolecules
A
A- Possess surface areas to enable binding to any targets
A- Molecular plagiarism speeds up discovery and development
D- Rarely cell permeable
3
Q
Classical Genetics
A
Isolate a mutant organism and sequence DNA to find the gene responsible
4
Q
Chemical Genetics
A
Use small molecules that alter protein function to find the gene
5
Q
How do Anti-TNF antibodies work?
A
- TNF receptor hooked up to an antibody
- Binds to TNF, then neutralize it so it can’t bind or help it clear from circulation (lowering TNF levels)
