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Pharmaceutical Chemistry > Siqueria-Neto > Flashcards

Siqueria-Neto Flashcards

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1
Q

Leishmaniasis: Chemotherapy

A
  • Pentavalent antimonials: sodium stibogluconate, SSG meglumine
  • Toxic side effects / drug resistance, 30+ days of IM/IV injection
  • AmBisome: liposomal amphotericin (polyene)
  • 1-5 days of IV injection
  • Miltefosine (phospholipid)
  • Only oral drug for VL
  • Paromomycin (aminoglycoside)
  • 21 days of IM injection
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2
Q

Leishmaniasis: Vector

A

Sandfly

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3
Q

Chagas: Chemotherapy

A
  • Benznidazole
  • Nifurtimox
  • Posaconazole
  • Ravuconazole
  • N & B are for acute treatment, but both are expensive, high risk of side effect, cannot be used in pregnancy / renal+hepatic insufficiency
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4
Q

Chagas: Vector

A

Kissing bug

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5
Q

Chagas: K777

A

Developed in 1996 by Dean McKerrow

  • Covalent inhibitor
  • Warhead: double bond next to sulfur
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6
Q

High Content Screening

A
  1. ) Assay
  2. ) Plate containing compounds
  3. ) Washing, fixing, staining
  4. ) Reading
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Pharmaceutical Chemistry (12 decks)

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