Structure and function of the cerebellum Part 2 Flashcards
What layers is the cerebral cortex made up of?
outer synaptic/receptive layer (molecular layer)
intermediate discharge layer (Purkinje cell layer)
inner receptive layer (granule cell layer)
How are the cells in the layers of the cerebral cortex arranged?
In circuit
What cells and fibres are in the outer synaptic/receptive layer (molecular layer)
Parallel fibres
Basket cell
Stellate cell
What cells and fibres are in the intermediate discharge layer (Purkinje cell layer)
Purkinje cell
Climbing fibres
What cells and fibres are in the inner receptive layer (granule cell layer)
Granule cell
Golgi cell
Mossy fibres
Where does the Purkinje cell originate and where does it project through
the intermediate discharge layer (Purkinje cell layer)
Dendrite project up into molecular cell layer
Where do the parallel fibres originate and where does it project through
In granular layer
Resides in molecular layer projecting onto Purkinje cells through the Purkinje layer
What activates the granular cells?
Mossy fibres
Where do the mossy fibres originate and where does it project through
In the brain or spinal cord
In granular layer and synapse onto granule cell
Where do the granular cells originate and where does it project through
In granular layer
Resides in molecular layer projecting onto Purkinje cells through the Purkinje layer
What are granulosa cells
Glutamatergic interneurons
What do granulosa cells release
Glutamate excitatory neurotransmitter
Where does information collated in the Purkinje fibres go?
Purkinje cell output —› deep cerebellar nuclei thalamus —> cerebral cortex
What acts as a feedforward in the cerebellum
Mossy fibre circuitry
regulating excitability of the Purkinje fibres
regulates the stimulation or input into the deep cerebellar nuclei
What acts as a feedback in the cerebellum
Climbing fibre circuitry
What is faster, the feedforward or feedback in the cerebellum
faster
Why is the feedforward in the cerebellum complicated
requires error prediction of the stimulus and delay responses appropriately
correcting the initial output to the deep nuclei before that output has happened
enables appropriate movement
What is the function of the feedback in the cerebellum
error correction
What are the nuclei in the deep cerebellar nuclei
dentate nucleus
globose and emboliform nuclei
fastigial nucleus
What is the path that information from the lateral hemisphere takes
Lateral hemispheric cortex —›DENTATE NUCLEUS —› sup. peduncle —›cerebral cortex (via thalamus).
What is the path that information from the paravermal cortex takes
Paravermal cortex —›GLOBOSE & EMBOLIFORM NUCLEI —›sup, peduncle—› red nucleus—› Lateral descending pathways
What is the path that information from the vermis takes
Vermis—› FASTIGIAL NUCLEUS—› inferior peduncle—› Medial descending pathways.
What is the path that information from the flocculondular lobe takes
Flocculonodular lobe—› FASTIGIAL NUCLEUS—› inferior peduncle—› vestibular nuclei & reticular
formation
What is the pathway from the lateral hemispheric cortex pathway involved in
Pre-programming movements,
