Structure and function of the blood vessels and heart- in the other pharmacy as well Flashcards
The cardiovascular system (CVS) speeds up
gas and solute transport over long distances (convection)
Function of the Cardiovascular System
delivery of O2 and nutrients to each cell
removal of CO2 and waste products from each cell
communication between organs through transport of hormones and other extracellular mediators
temperature regulation
crucial hydrodynamic device in sexual reproduction!
Blood pressure is determined by three main factors
cardiac output
peripheral resistance
blood volume
Cardiovascular circulation can be divided
into the systemic and pulmonary (lung) circuits with the heart as the central pump
systemic veins-vena cavae- heart-pulmonary truck and arteries - pulmonary vein- heart- systemic arteries
Blue color represents
blood that is only
partially oxygenated
What is the composition of blood?
Plasma (water, ions, proteins, nutrients, hormones, metabolic wastes, gases, etc)
o2 transport
Most of blood is distributed in the
veins and venules (act as a reservoir)
Blood Distribution (at rest)
pulmonary circulation-12
heart-9
arteres-11
arterioles and capillaries-7
veins and venules-61
Blood Flow (at rest)
At rest….most blood is flowing through abdominal organs and kidneys
Majority of pumping is in parallel which means that all flow through organs is not linked. Some execeptions including intensines which run into liver….carry food. However if blood flow is occulled then reduction in blood to liver
Heart flow is quite small and any small change in flow and therefore oxygen can lead to reduce O2 and pain (called angina)
Blood vessels contain multiple cell layers that regulate their function
lumen
Endothelial cells (Tunica Intima)
Smooth muscle cells (Tunica Media)
Connective tissue (Tunica Adventita)
All blood vessels contain endothelial cells but vary in the thickness of the smooth muscle and connective tissue
Blood vessels involved in the circulation
away from the heart oxygenated
arteries
arterioles
capillaries - exchange microcirculation
towards the heart deoxygenated
venules
veins
Arteries contain
a large lumen and a thick layer of
smooth muscle (tunica media) and connective tissue (tunica adventitia)
Thick layer of elastic smooth muscle acts as a pressure reservoir
Arterioles contain
a thin muscular wall and a small lumen
Contraction of the smooth muscle regulates the diameter of the lumen
- Determine blood flow to organs
- Major determinant of mean arterial pressure
Capillaries have a
single layer of endothelial cells
Exchange of nutrients, oxygen and waste across the capillary wall but NOT proteins
Intercellular clefts and fused vesicles channels assist the exchange.
Exchange is facilitated by the slow movement of blood and large surface area within the capillaries
large surface are so faster
Venules and veins contain
thin walls, large diameter lumen and valves
Thin small muscle layer and large diameter lumen – allow storage of large blood volume (~ 60% of total blood volume)
Return of venous blood to the heart is facilitated by valves and the skeletal muscle pump
Varicose veins
broken valves allow the blood to flow backwards under gravity