Structure and Function of Skin III Flashcards
The dermo-epidermal junction is found where?
Between the epidermis and the dermis
Give two examples of what the DE junction does.
Provides nutrition to epidermis Stops dermis slipping off Semi-permeable membrane (barrier and filter)
What are the three layers of the DE junction from top to bottom?
Lamina lucida Lamina densa Sub-lamina densa zone
Bullous pemphigoid is a skin condition caused by?
Antibodies attacking the proteins in the DE junction
Give some examples of cells found in the dermis.
Fibroblasts Macrophages Mast cells Lymphocytes Langerhans cells
Describe the route of blood flow in the skin
Blood flows from: Arteriole -> precapillary sphincters -> venous capillaries -> post-capillary venules -> collecting venules
What is the cause of angioma?
Overgrown blood vessels causing dilation
What is the function of lymphatic vessels in the blood supply?
Drain any debris (plasma proteins etc.) left by the blood supply
Blockage of the lymph vessels causes?
Lymphoedema
Which receptors are responsible for somatic sensory sensation?
Pacinian corpsucles (pressure) Meissner’s corpsucles (vibration
The autonomic nerve supply innervates which structures in the skin?
Blood vessels Nerves Glands
Which corpsucles sit higher in the dermal layer
Meissner’s corpsucles
Histologically, Pacinian corpsucles look like what?
Onions
In what genetic condition is there an overgrowth of nerve endings?
Neurofibromatosis
What are the three main skin glands?
Sebaceous Apocrine Eccrine
Name these sweat glands
