Cutaneous Drug Eruptions Flashcards
How do most skin drug eruptions present?
Exanthematous
Morbilliform
Maculopapular
Give some risk factors for the development of drug eruptions
Gender
Genetics
Concomitant disease
Immune status
An exanthematous drug eruption is …-cell mediated.
T
How do patients with an exanthematous drug eruption present?
Itchy
Widespread symmetrical rash
Mild fever
What would suggest a severe exanthematous drug eruption?
Involvement of face/mucous membrane Facial oedema Blisters Lymphadenopathy Wheezing
Give some drugs known to cause exanthematous drug eruptions
Penicillins
Erythromycin
NSAIDs
A uticarial drug reaction is usually … mediated
IgE
Examples of pustular/bullous drug eruptions include
Acne
Acute generalised exanthematous pustulosis (AGEP)
Fixed drug eruptions appear on the skin as?
Well demarcated round plaques
How can fixed drug eruptions present?
Lesions
Papules
Vesicles
Uticaria
What drugs are associated with fixed drug eruptions?
Tetracycline/doxycycline
Paracetamol
NSAIDs
Give some examples of severe cutaneous drug reactions
Stevens-Johnson syndrtome
Toxic epidermal necrolysis
What is a phototoxic cutaneous drug reaction?
A non-immunological skin reaction causing increased sensitivity to sunlight
What drugs are associated with phototoxicity?
Antibiotics
Thiazides
NSAIDs
Amiodarone
What investigations can be done in spontaneous drug eruptions?
Biopsies
Patch test
Skin prick testing
Phototesting
