Structural Aberrations: Inversions Flashcards

1
Q

This results from two chromosomal breaks with inversion through 180° of the segment between the breaks.

A

Inversions

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2
Q

In this type of inversions, the breaks are on either side of the centromere and it is included in the inversion.

A

Pericentric inversion

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3
Q

In this type of inversions, the breaks are in a single arm, and the centromere is not included in the inversion.

A

Paracentric inversion

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3
Q

In chromosomes with inversion, homologous pairing usually required that one member form a ____ in the region of the inversion.

A

loop.

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3
Q

T/F. Inversions interfere with the pairing of homologous chromosomes during meiosis, and crossing-over tends to be suppressed within the inverted segment.

A

True.

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3
Q

T/F. Generally, inversions causing change in gene order does not produce clinical abnormality. The medical significance lies with the increased risk of generating unbalanced gametes

A

True

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4
Q

For a paracentric inversion, if a cross-over does occur within the loop, then this will result in a ____ and an ____ fragment.

A

dicentric chromatid; acentric

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5
Q

In contrast, for a pericentric inversion, if an ____ number of cross-overs occurs within the loop, then each of the two chromatids produced will have both a ____ and a ____, and abnormal offspring may be produced

A

uneven number; deletion; duplication

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6
Q

T/F. In inversions, the closer both breakpoints are to the telomeres, the smaller the duplication and deletion and thus the higher the likelihood of survival of the fetus until birth.

A

True.

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7
Q

In contrast to inversions, _____ involves no change in gene order and little consequence to offspring.

A

centromere repositioning

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