Structural Aberration: Isochromosomes Flashcards
1
Q
Is an abnormal chromosome that has a deletion of one arm with duplication of the other.
A
isochromosomes
2
Q
Isochromosomes arise from…
A
transverse division of the centromere during cell division
isochromatid break and fusion above the centromere (in which case it is dicentric)
3
Q
What is the commonest isochromosome in live births?
A
isochromosome of the long arm of X, or i(Xq)
4
Q
Isochromosome of the long arm of X results in what disease due to short-arm monosomy and long-arm trisomy.
A
Turner syndrome
5
Q
Isochromosomes in live births
A
long arm of X
Isochromosome of Y
short arms of 9, and 12
6
Q
In many instances, isochromosomes are dicentric, but one centromere becomes non-functional so that the chromosome segregates normally during cell division.
A
True
