stress and disease Flashcards
what is stress
Perceived or anticipated threat that disrupts a person’s wellbeing or homeostasis
stress is caused by—
stressors
homeostasis is
a state of balance among all the body systems needed for the body to survive and function correctly
allostasis
is the state of achieving new homeostasis due to a stressor
allostatic overload
Is when the stressor is significant and the body fails to reach a new equilibrium
What are the stress systems
- Hypothalamic-pituitary adrenal
- sympathetic nervous system
- Immune system
hypothalamic-pituitary adrenal
hypothalamus secretes– corticotropin hormone
pituitary secretes– adrenocorticotropin hormone
adrenal gland– cortisol
What does the acute release of cortisol do to the body
- regulates sleep, mood, growth and reproduction, cognition, arousal, and cardiovascular tone
- increases blood sugar level or stimulates glucogenesis
- increases powerful anti-inflammatory and immunosuppressive agent
Chronic release of cortisol release leads to
- sleep deprivation, obesity, type 2 diabetics, hypertension, less bone density
- cognitive impairment and emotional disorder
- gastric ulcers
Sympathetic nervous system activates the releasing of —–
Catecholamines which are norepinephrine and epinephrine
What are the effects of catecholamines
- stimulates alpha and beta androgenic receptors
- regulates the skeletal, cardiovascular, hepatic, immune system and pulmonary systems
-increases proinflammatory cytokine production
chronic release of norepinephrine causes
- stroke
-plaque formation in the blood vessels
-sickness syndrome
the immune system activates
- responds to stress
- alert other signals about the stress
- stress can either suppress or enhance immune cell function by stimulating endogenous opiate
Chronic stress may cause
- immune degranulation
- decrease natural killers and T-cytotoxic
- increase tumor growth and metastasis of tumor
- burnout
- chronic inflammatory responses include
- cardiovascular disease, type 2 diabetics, osteoporosis, COPD, and arthritis
What are the effects of telomeres
increases cell death and causes early death