Stras: CSF Flashcards

1
Q
  1. The functions of the CSF include all of the
    following except:
    A. Removal of metabolic wastes
    B. Producing an ultrafiltrate of plasma
    C. Supplying nutrients to the CNS
    D. Protection of the brain and spinal cord
A

B. Producing an ultrafiltrate of plasma

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2
Q
  1. The CSF flows through the:
    A. Choroid plexus
    B. Pia mater
    C. Arachnoid space
    D. Dura mater
A

C. Arachnoid space

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3
Q
  1. Substances present in the CSF are contolled by the:
    A. Arachnoid granulations
    B. Blood-brain barrier
    C. Presence of one-way valves
    D. Blood-CSF barrier
A

B. Blood-brain barrier

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4
Q
  1. The CSF tube labeled 3 is sent to:
    A. The hematology department
    B. The chemistry department
    C. The microbiology department
    D. The serology department
A

A. The hematology department

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5
Q
  1. The CSF tube that should be refrigerated is:
    A. Tube 1
    B. Tube 2
    C. Tube 3
    D. Tube 4
A

C. Tube 3

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6
Q

Even distribution of blood in all tubes

A

Intracranial hemorrhage

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7
Q

Xanthochromic supernatant

A

Intracranial hemorrhage

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8
Q

Concentration of blood in tube 1 is greater than in tube 3

A

Traumatic tap

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9
Q

Specimen contains clots

A

Traumatic tap

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10
Q

The presence of xanthochromia can be caused by all of the following except:
A. Immature liver function
B. RBC degradation
C. A recent hemorrhage
D. Elevated CSF protein

A

C. A recent hemorrhage

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11
Q
  1. A web-like pellicle in a refrigerated CSF specimen is indicative of:
    A. Tubercular meningitis
    B. Multiple sclerosis
    C. Primary CNS malignancy
    D. Viral meningitis
A

A. Tubercular meningitis

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12
Q
  1. Given the following information, calculate the CSF WBC count: cells counted, 80; dilution, 1:10; large Neubauer squares counted, 10.
    A. 8
    B. 80
    C. 800
    D. 8000
A

C. 800

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13
Q
  1. A CSF WBC count is diluted with:
    A. Distilled water
    B. Normal saline
    C. Acetic acid
    D. Methylene blue
A

C. Acetic acid

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14
Q
  1. A total CSF cell count on a clear fluid should be:
    A. Reported as normal
    B. Not reported
    C. Diluted with normal saline
    D. Counted undiluted
A

D. Counted undiluted

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15
Q
  1. The purpose of adding albumin to CSF before cytocentrifugation is to:
    A. Increase the cell yield
    B. Decrease the cellular distortion
    C. Improve the cellular staining
    D. Both A and B
A

D. Both A and B

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16
Q
  1. The primary concern when pleocytosis of neutrophils and lymphocytes is found in the CSF is:
    A. Meningitis
    B. CNS malignancy
    C. Multiple sclerosis
    D. Hemorrhage
A

A. Meningitis

17
Q
  1. Neutrophils with pyknotic nuclei may be mistaken for:
    A. Lymphocytes
    B. Nucleated RBCs
    C. Malignant cells
    D. Spindle-shaped cells
A

B. Nucleated RBCs

18
Q
  1. The presence of which of the following cells is increased when a CNS shunt malfunctions?
    A. Neutrophils
    B. Macrophages
    C. Eosinophils
    D. Lymphocytes
A

C. Eosinophils

19
Q
  1. Macrophages appear in the CSF following:
    A. Hemorrhage
    B. Repeated spinal taps
    C. Diagnostic procedures
    D. All of the above
A

D. All of the above

20
Q
  1. Nucleated RBCs are seen in the CSF as a result of:
    A. Elevated blood RBCs
    B. Treatment of anemia
    C. Severe hemorrhage
    D. Bone marrow contamination
A

D. Bone marrow contamination

21
Q
  1. Following a CNS diagnostic procedure, which of the following might be seen in the CSF?
    A. Choroidal cells
    B. Ependymal cells
    C. Spindle-shaped cells
    D. All of the above
A

D. All of the above

22
Q
  1. Hemosiderin granules and hematoidin crystals are seen in:
    A. Lymphocytes
    B. Macrophages
    C. Ependymal cells
    D. Neutrophils
A

B. Macrophages

23
Q
  1. Myeloblasts are seen in the CSF:
    A. In bacterial infections
    B. In conjunction with CNS malignancy
    C. Following cerebral hemorrhage
    D. As a complication of acute leukemia
A

D. As a complication of acute leukemia

24
Q
  1. Cells resembling large and small lymphocytes with cleaved nuclei represent:
    A. Lymphoma cells
    B. Choroid cells
    C. Melanoma cells
    D. Medulloblastoma cells
A

A. Lymphoma cells

25
Q
  1. The normal value of CSF protein is:
    A. 6–8 g/dL
    B. 15–45 g/dL
    C. 6–8 mg/dL
    D. 15–45 mg/dL
A

D. 15–45 mg/dL

26
Q
  1. CSF can be differentiated from plasma by the
    presence of:
    A. Albumin
    B. Globulin
    C. Prealbumin
    D. Tau transferrin
A

D. Tau transferrin

27
Q
  1. In plasma, the second most prevalent protein is IgG; in CSF, the second most prevalent protein is:
    A. Transferrin
    B. Prealbumin
    C. IgA
    D. Ceruloplasmin
A

B. Prealbumin

28
Q
  1. Elevated CSF protein values can be caused by all of the following except:
    A. Meningitis
    B. Multiple sclerosis
    C. Fluid leakage
    D. CNS malignancy
A

C. Fluid leakage

29
Q
  1. The integrity of the blood-brain barrier is measured using the:
    A. CSF/serum albumin index
    B. CSF/serum globulin ratio
    C. CSF albumin index
    D. CSF IgG index
A

A. CSF/serum albumin index

30
Q
  1. Given the following results, calculate the IgG index: CSF IgG, 50 mg/dL; serum IgG, 2 gm/dL; CSF albumin, 70 mg/dL; serum albumin, 5 gm/dL.
    A. 0.6
    B. 6.0
    C. 1.8
    D. 2.8
A

C. 1.8

31
Q
  1. The CSF IgG index calculated in Study Question 27 is indicative of:
    A. Synthesis of IgG in the CNS
    B. Damage to the blood-brain barrier
    C. Cerebral hemorrhage
    D. Lymphoma infiltration
A

A. Synthesis of IgG in the CNS

32
Q
  1. The finding of oligoclonal bands in the CSF and not in the serum is seen with:
    A. Multiple myeloma
    B. CNS malignancy
    C. Multiple sclerosis
    D. Viral infections
A

C. Multiple sclerosis

33
Q
  1. A CSF glucose of 15 mg/dL, WBC count of 5000, 90% neutrophils, and protein of 80 mg/dL is suggestive of:
    A. Fungal meningitis
    B. Viral meningitis
    C. Tubercular meningitis
    D. Bacterial meningitis
A

D. Bacterial meningitis

34
Q
  1. A patient with a blood glucose of 120 mg/dL would have a normal CSF glucose of:
    A. 20 mg/dL
    B. 60 mg/dL
    C. 80 mg/dL
    D. 120 mg/dL
A

C. 80 mg/dL

35
Q
  1. CSF lactate will be more consistantly decreased in:
    A. Bacterial meningitis
    B. Viral meningitis
    C. Fungal meningitis
    D. Tubercular meningitis
A

B. Viral meningitis

36
Q
  1. Measurement of which of the following can bereplaced by CSF glutamine analysis in children with Reye syndrome?
    A. Ammonia
    B. Lactate
    C. Glucose
    D. -ketoglutarate
A

A. Ammonia

37
Q
  1. Prior to performing a Gram stain on CSF, the specimen must be:
    A. Filtered
    B. Warmed to 37C
    C. Centrifuged
    D. Mixed
A

C. Centrifuged

38
Q
  1. All of the following statements are true about
    cryptoccocal meningitis except:
    A. An India Ink preparation is positive
    B. A starburst pattern is seen on Gram stain
    C. The WBC count is over 2000
    D. A confirmatory immunology test is available
A

C. The WBC count is over 2000

39
Q
  1. The test of choice to detect neurosyphilis is the:
    A. RPR
    B. VDRL
    C. FTA
    D. FTA-ABS
A

B. VDRL