Straight up antibiotics

Question 1

Mode of action: disrupt the phospholipoprotein membrane

Answer 1

mode of action polymyxins polyenes Azoles

Question 2

Voriconazole

Answer 2

disrupt the phospholipoprotein membrane DOC for systemic mycosis, especially aspergillosis in AIDS patients Crosses BBB

Question 3

Triazoles

Answer 3

disrupt the phospholipoprotein membrane Examples are Fluconazole (diflucan) and Voriconazole

Question 4

Polymyxin E (colistin)

Answer 4

disrupt the phospholipoprotein membrane i. In Thayer-Martin Chocolate Agar ii. Treats otitis externa

Question 5

Polymoxins

Answer 5

disrupt the phospholipoprotein membrane isolated from bacillus amphithatic Examples are polymyxin B and Polymyxin E (aka colistin)

Question 6

Pencillins

Answer 6

Young G+ only (G+ have more murein) - G+ have higher internal pressure so breakdown of murein is drastic Examples are natural penicillins repository penicillins semi-synthetic penicillins Beta lactamase penicillins

Question 7

aspergillosis

Answer 7

disrupt the phospholipoprotein membrane causes systemic mycosis dimorphic fungi in immunodifficent patients at 25*C looks like mold at 37*C looks like yeast

Question 8

Fluconazole (diflucan)

Answer 8

disrupt the phospholipoprotein membrane DOC for deep or superficial Candidias

Question 9

Mode of Action: suppress cell wall synthesis

Answer 9

mode of action penicillins cephalosporins carbapenems bactracin vancomycin

Question 10

Natural penicillins

Answer 10

naturally occuring examples are benzyl penicillin (G) and phenoxymethyl penicllin (V)

Question 11

Polyenes

Answer 11

disrupt the phospholipoprotein membrane toxic come from streptomyces treats fungal infections inhibits sterols Examples are Nustatin and Amphotericin B

Question 12

Amphotericin B

Answer 12

disrupt the phospholipoprotein membrane i. Passes through BBB ii. IV if infection is serious iii. DOC for systemic mycosis caused by aspergillosis

Question 13

Polymyxin B

Answer 13

disrupt the phospholipoprotein membrane i. Treats resistant actinobacter, otitis externa, ophthalmic infections ii. In triple antibiotic ointment iii. G- only iv. Toxic (Nephro/neurotoxin)

Question 14

Azoles

Answer 14

disrupt the phospholipoprotein membrane Examples: Imidazoles Triazoles

Question 15

Imidazoles

Answer 15

disrupt the phospholipoprotein membrane attack sterols Examples are clotrimazole, miconazole, and ketoconazole

Question 16

Clotrimazole and Miconazole

Answer 16

disrupt the phospholipoprotein membrane Treats ringworm, athlete’s foot, volvovaginits (epidermopyton, microsporum, trichophyton)

Question 17

Nystatin

Answer 17

disrupt the phospholipoprotein membrane i. Treats dermatophytic (superficial) candidas albicans (thrush, vulvovagitis) Is a polyene

Question 18

mode of action polymyxins polyenes Azoles

Answer 18

Mode of action: disrupt the phospholipoprotein membrane

Question 19

disrupt the phospholipoprotein membrane DOC for systemic mycosis, especially aspergillosis in AIDS patients Crosses BBB

Answer 19

Voriconazole

Question 20

disrupt the phospholipoprotein membrane Examples are Fluconazole (diflucan) and Voriconazole

Answer 20

Triazoles

Question 21

disrupt the phospholipoprotein membrane i. In Thayer-Martin Chocolate Agar ii. Treats otitis externa

Answer 21

Polymyxin E (colistin)

Question 22

disrupt the phospholipoprotein membrane isolated from bacillus amphithatic Examples are polymyxin B and Polymyxin E (aka colistin)

Answer 22

Polymoxins

Question 23

Young G+ only (G+ have more murein) - G+ have higher internal pressure so breakdown of murein is drastic Examples are natural penicillins repository penicillins semi-synthetic penicillins Beta lactamase penicillins

Answer 23

Pencillins

Question 24

disrupt the phospholipoprotein membrane causes systemic mycosis dimorphic fungi in immunodifficent patients at 25*C looks like mold at 37*C looks like yeast

Answer 24

aspergillosis

Question 25

disrupt the phospholipoprotein membrane DOC for deep or superficial Candidias

Answer 25

Fluconazole (diflucan)

Question 26

mode of action penicillins cephalosporins carbapenems bactracin vancomycin

Answer 26

Mode of Action: suppress cell wall synthesis

Question 27

naturally occuring examples are benzyl penicillin (G) and phenoxymethyl penicllin (V)

Answer 27

Natural penicillins

Question 28

disrupt the phospholipoprotein membrane toxic come from streptomyces treats fungal infections inhibits sterols Examples are Nustatin and Amphotericin B

Answer 28

Polyenes

Question 29

disrupt the phospholipoprotein membrane i. Passes through BBB ii. IV if infection is serious iii. DOC for systemic mycosis caused by aspergillosis

Answer 29

Amphotericin B

Question 30

disrupt the phospholipoprotein membrane i. Treats resistant actinobacter, otitis externa, ophthalmic infections ii. In triple antibiotic ointment iii. G- only iv. Toxic (Nephro/neurotoxin)

Answer 30

Polymyxin B

Question 31

disrupt the phospholipoprotein membrane Examples: Imidazoles Triazoles

Answer 31

Azoles

Question 32

disrupt the phospholipoprotein membrane attack sterols Examples are clotrimazole, miconazole, and ketoconazole

Answer 32

Imidazoles

Question 33

disrupt the phospholipoprotein membrane Treats ringworm, athlete’s foot, volvovaginits (epidermopyton, microsporum, trichophyton)

Answer 33

Clotrimazole and Miconazole

Question 34

disrupt the phospholipoprotein membrane i. Treats dermatophytic (superficial) candidas albicans (thrush, vulvovagitis) Is a polyene

Answer 34

Nystatin