Lecture 17 Flashcards
What are azols used for?
Anti-fungal
What is the mode of action for azols?
Disruption of the phosolipoprotien membrane
What are the two major types of azols?
- Imidazoles
2. Triazoles
Name the triazols
Fluconazol (difucan)
Voriconazole
Name the imidazoles
Clotrimazole
Miconazole
Ketoconazole
What is the mode of action for clotrimazole?
Disruption of the phosolipoprotien membrane
What is clotrimazole used for?
Systemic mycoses
Although clotrimazole is unable to penetrate the blood brain barrier, why have newer drugs been chosen over it?
It is more toxic than modern day alternatives
What is the mode of action for miconazole?
Disruption of the phosolipoprotien membrane
Miconazole is used for what disease?
Candiasis when it is superficial (vulvovaginitis)
Ketoconazole works with what kind of mode of action?
Disruption of the phosolipoprotien membrane
In what form are clotrimazole, miconazole and ketoconazole normally found in?
A topical cream
Ketoconazole is used to treat what?
Cadiasis when it is superfical (vulvovaginitis)
All three imidazoles can be used to treat what infection?
Mild infections of ringworm or athlete’s foot (caused by microsporum, trichophyton, and epidermophyton)
Fluconazol is also called what?
Diflucon
What is the mode of action for fluconazol?
Disruption of the phosolipoprotien membrane
What is fluconazol used to treat?
Yeast infections, not really molds
Voriconazole is a DOC for what?
Systemic mycoses
What drug is able to penetrate the blood brain barrier, making it effective against aspersillosis?
Voriconazole
What organism produces polyene antibiotics? Where is this organism found?
streptomyces which is found in the soil
What is the mode of action of polyene antibiotics?
attacks the cell membrane by binding with sterols
What organisms do polyene antibiotics effect?
us and fungi
they do not work against bacteria as they don’t have sterols in their membrane
Name the sterol in human cell membranes
cholesterol
name the sterol in fungi cell membranes
ergosterol
Are polyene antibiotics cidal, inhibitory, static, or ineffective against their intended target?
cidal
Name the 2 types of polyene antibiotics
nystatin and amphotericin B
What is Nystatin a DOC for? what is it an alternate for?
It is not a DOC or an alternate for anything
What is Nystatin commonly used against?
dermatophyte yeast infections (superficial on the skin’s surface)