stomach Flashcards

1
Q

when is a second CT sim done

A

when pt loses >10% body weight or when the patient has anatomy changes d/t weight loss

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2
Q

prep for ct SIM/ tx

A

both CT sim and tx pt should fast for 3 hours prior

CT sim pt will have both oral and IV contrast and will have a 4DCT scan to track tumour motion during tx

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3
Q

patient position for treatment

A

pt typically will have wing board +/- vac loc and triangle under knees, arms should b above head

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4
Q

CT scanning limits

A

t4-5 to ischial tuberosities

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5
Q

OARS in general

A

kidney, heart, liver, spinal cord, small bowel

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6
Q

kidney OAR

A

2/3 of one kidney should be spared
For proximal lesions >50% lt kidney is in the field therefore rt kidney should be spared
for distal lesions the lRT kidney is in the field and should be spared as much as possible

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7
Q

what is included in CTV of tumours of the proximal GE/gastric lesions

A

the tumour + LN + 3-5 cm of the distal esophagus

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8
Q

CTV of esophagus

A

tumour +1.5-2cm margin and LN
(perigastric, celiac, portahepatis, supra pancreatic, splenic hilar, pancreatic duodenal, local PA and retroperitoneal LN

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9
Q

avg field size

A

15x 15

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10
Q

tx borders

A

s: t7-8
I: l3-4
lat: edge of body
M: 2-4 cm from vertebral bodies

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11
Q

energy

A

10-18MV

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12
Q

DOSES

A

45-50.4/25-28

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13
Q

MOST common s &s

A

appetite loss, early satiety, abode discomfort, wt loss, anemia, n &v and tarry stools

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14
Q

duration of symptoms

A

<3 mos in 40% pst

>1 year in 20 % ptr

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15
Q

what s&s is most common in the anTRUM AND cardia

A

vomiting and dysphagia

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16
Q

+ common age

A

50-70 yo

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17
Q

M vs f

A

+ common in men

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18
Q

most common nationalities

A

most common in back hispanics and native americans than whites

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19
Q

most common pathology

A

adenocarcinoma

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20
Q

adenocarcinoma subtypes

A

diffuse and intestinal

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21
Q

which adenocarcinoma has the worst prognosis

A

diffuse

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22
Q

which adenocarcinoma subtype is most common

A

intestinal

23
Q

where does intestinal and diffuse lesions most commonly occur

A

intestinal occur in distal areas and diffuse occur more commonly in the cardia

24
Q

proximal vs distal tumours regarding nationality

A

proximal moe common in whites and distal tumours more common in astern countries

25
what etiological factors are associated with intestinal adenocarcinoma
chronic gastritis, h pylori, tobacco, salt intake ( + common in eastern counters)
26
what etiological factors are associated with diffuse adenocarcinoma
mutation of e cahedrin
27
what infections can cause gastric cancer
H pylori and chronic EBV infections
28
what conditions can cause stomach cancer
gastric ulcers, barretts esophagus, lynch syndrome, pernicious anemia,
29
what blood type has and + risk and - risk of gastric cancer
o blood has - risk and a has + risk
30
what lifestyle factors + risk
no refrigeration diet high in salt, pickled, nitrites and low in fruits and vegetables, smoking, working in the rubber industry
31
portions of the stomach
funds body pylorus and cardia
32
GEJ T lvl
T11
33
pylorus T level
L1
34
LYMPHATIC DRAINAGE
Ln along the curvatures (gastric and gastropoelic) then splenic, hepatic and celiac
35
4 layers of the stomach
serosa, mucosa, submucosa and muscular externa
36
distant mets for various parts of he stomach
GE junction can spread to either lungs or liver | rest of the stomach spread to live via portal veins
37
most common location of the primary
pylorus 40% cardia 305 BODY 20 %
38
typical tx for stage 1-2
surgery followed by chemo +/- XRT (45/25 given if the patient is LN + )
39
How many ppl are dx at stage 1-2
<5% PTS DIAGNOSED AT this stage in north america
40
surgical procedures & areas
for body and pylorus- radical subtotal mastectomy- 80% of the stomach, perigastric, gastrohepatic gastric omen and duodenum are resected proximal area get total mastectomy
41
what is required to cure gastric cancer
a resection is required to make the cancer curable
42
adjuvant chemorads for stage 1b-2
after surgery 1) 5fu + cisplatinum is given (5FU days 1-21) and cisplatinum on days 1-5 2) concurrent chemoads ( 5fu + paclitaxel) given daily 5 days a week during XRT
43
TREATMENT FOR STAGE 3
if initially unresectable: chemorads then surgery if resectable surgery then chemorads
44
initially unresectable stage 3 treatment
induction chemo with 5fu, cisplatinum and paclitaxel then chemorads with 40-45/25 + paclitaxel +5fu then the tumour can be restaged and resected
45
completely unresectable treatment
35-40Gy EBRT + 5FU
46
average time from curative tx to palliation
4-18 mos
47
tx options for stage 4 tx
palliative chemo or XRT for pain relief
48
chemo agents for metastatic disease
5FU-doxorubicin and methotrexate
49
what staging systems are used
bormanns types and TNM
50
Bormanns types
1) polypoid and fun gating 2) ulcerating w elevated borders 3) ulceration w invasion to gastric walls 4) diffusely infiltrating 5) unclassifiable
51
what bormanns types are good prognosis and bad prognosis
1) polypoid and fun gating and 2) ulcerating ad elevated borders are good and type 4) diffusely infiltrating is poor prognosis
52
what is the first XRT INDUCED SIDE EFFECT THAT WILL START
N & V can start right away
53
side effects
anorexia, N&V, fatigue and diarrhea
54
medications to be used for side effects
antiemetics: OTC- gravel RX-kytril, zofran and stemetil Antidiahhreals: OTC- ammonium and kapatocar RX- lomotil