pediatrics Flashcards
most common paediatric cancer
ALL (acute lymphocytic leukaemia)
lymphoma is the ___most common paediatric cancer
3rd
age for lymphomas in children
common in 4-14 y.o.
what causes HD in kids
HD in kids is common in EBV in developing countries
what HD is common in what age group
nodular sclerosing is most common in adults and adolescents less common in children
mixed cellularity is more common in children
most children with lymphoma present with what kind of LN
cervical lymphadenopathy
is mediastinal involvement more common in children or adolescents with lymphoma
mediastinal involvement affects 75% of adolescents and is less common 33% in children 1-10y,o,
prognostic factors for lymphoma in chilren
stage is most important to determine treatment
b symptoms have a higher risk of relapse
T4 has worse prognosis
WBC count above 11500 hemoglobin less than 11 g/dl
lymphocyte depleted has a worse prognosis than other subtypes
children <10 have better prognosis
howccommon are the presentation of b symptoms in paediatric lymphoma pts
1/3 of patients present with b symptoms
fever >38c
night sweats
weight loss >10% of its body weight in 6 months
primary treatment for paediatric lymphoma patients
chemo
most common paediatric brain tumours
low grade gliomas medulloblastomas gliomas ependymomas craniopharyngiomas pineal region tumurs embryonal rumours choroid plexus tumours
treatment for low grade gliomas for patients <10 and >10
<10 SX+CX then XRT RESERVED FOR PROGRESSION
>10 XRT up front
planning for paediatric low grade gliomas CTV
CTV expansion of 5 mm for localized tumours and dose of 54/30
high grade glioma treatment
start with surgery adjuvant XRT5940/33
2nd most common types of paediatric tumours
brain tumours
XRT alone in lymphoma of paeds
Radiation alone is almost never done
Possible exception is the fully grown child with localized nodular lymphocyte predominant HD
dose for XRT for paeds
low dose 15-25.5Gy
is hodgkins or non hodgkins more common in paeds
Non hodgkins is more common
most common nodal areas involved in NHD
Abdomen is most common followed by mediastinum
use of XRT in paediatric brain tumours
reserved for unresectable or recurrent lesions 50-54Gy
CTV,PTV for low grade astrocytomas pediatric
CTV-1.5cm around GTV
PTV-.5cm around CTV
Treatment optic glioma
chemo for younger patients, 50-54Gy with IMRT, proton or 3DCRT
What can cause optic glioma in children
neurofibromatosis
where does ependymoma arise from
from the ependyma cells that line the ventricles
presenting symptoms of ependymoma paper like what other CNS tumour?
medulloblastoma
treatment of ependymoma in children
treated by a gross total resection XRT after surgery is generally given if CSF seeding is noted then CSI XRT is given 1cm CTV is treated to 5400-5940 cGy chemo is given neo or adjuvantly if the tumour is unresectable
medullablastoma is a _____fossa malignancy
posterior
medulloblastoma constitutes ___% of all childhood brain tumours
20
medulloblastoma arises from what type of cells
cerebellar stem cells
histologic appearance of medulloblastoma
small round blue cells
invasion of medulloblastoma
arises midline of cerebellum, invades 4th ventricles and brainstem and high propensity to invade CSF
Distant mets in medulloblastoma
can occur most likely to the bone
treatment for medulloblastoma
posterior occipital craniotomy is used followed by adjuvant XRT CSI 2340-5400 followed by chemotherapy
where do germ cell tumours arise from
develop from embryologic nests of tissue in midline brain usually in the suprasellar or pineal region
germinoma is radio ——–.
sensitive
what is the most common type of paediatric germ cell tumours
germinoma
treatment germ cell tumour
low dose csi followed by tumour boost to 50 Gyor cisplatinum based chemo followed by XRT boost
non germinomas are treated with all 3: cispltinum chemo, art and XRT boost