Miscellaneous Flashcards

1
Q

dose erythema

A

30gy

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2
Q

Dose dry desquamation

A

40Gy

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3
Q

dose moist desquamation

A

50gY

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4
Q

Dose xerostomia

A

10Gy

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5
Q

dose dysphagia

A

30Gy

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6
Q

orthopnea

A

difficult time breathing when lying down - regional Lung symptom

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7
Q

Pancoast tumours are what subtype?

A

usually NSCLC

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8
Q

SCC (squamous cell of the lung) is located where? cause? M vs f

A

centrally, M, due to cigarette smoking

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9
Q

adenocarcinoma of the lung is located where? M vs F

A

occur in Women more commonly and and are more peripheral

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10
Q

where to SCC occur (small cell)

A

centrally

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11
Q

where do large cell cancers occur?

A

occur peripherally

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12
Q

dose for mucositis

A

3000

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13
Q

dos for dry eye

A

4000

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14
Q

dose for laryngitis

A

5000

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15
Q

dose for trismus

A

6000

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16
Q

KV for which field Mv for which field for breast

A

this is done for 4 field breast
sclav tx with KV
CHWL with MV

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17
Q

otalgia

A

ear pain

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18
Q

what is the term for all blood counts being decreased

A

pancytopenia

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19
Q

weight loss severe vs significant

A
Significant Weight Loss
1 - 2% over 1 wk
5% over 1 mo
7.5% over 3 mo
10% over 6 mo
Severe Weight Loss
>2% over 1 wk
>5% over 1 mo
>7.5% over 3 mo
>10% over 6 mo
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20
Q

dose esophagitis

A

20Gy

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21
Q

dose nausea & vomiting

A

10-20

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22
Q

dose diarrhrea

A

20-50gy

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23
Q

contraindications cisplatinum

A

kidney probs

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24
Q

contraundications vincristine

A

liver probs

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25
Q

contraindications adryiamyacin

A

heart

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26
Q

contraindications doxorubicin

A

heart

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27
Q

contraindications cyxlophophamide

A

kidney

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28
Q

antinausea meds

A

llorazepam, kytril, odansetron

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29
Q

typical pulse

A

60-100

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30
Q

typical respirations

A

12-20

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31
Q

typical temperatur

A

37 c or 98.6 F

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32
Q

fever temp

A

37.6 c

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33
Q

examples of droplet precautions

A
  • WHOOPING COUGH
  • MENINGITIS
  • COVID 19
  • FLU
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34
Q

what is nosocomial infection

A

infection that occurs d/t exposure in helth care facitlity

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35
Q

precautions droplet

A
think COVID 
surgical mask (on pt, on HCW, on visitors) 
gloves and gown
eye protection 
limit mvmnet of pts
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36
Q

airborne precaustions disease

A

neasles MMR TB

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37
Q

airborne precautions tx

A

N95, surgical mask, observe cough etiquette, limit mvmt, keep doors closed

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38
Q

contact precautions diseases

A

MRSA, VRE, cdiff

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39
Q

contact precautions PPE

A

hand hygeinge is very important
gloves and gowns
dispose gloves carefully
clean equipment carefully

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40
Q

who sets in place dose limits

A

CNSC

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41
Q

what NEW’s will get a dosimeter

A

any MRT that will receive 1/20th of the dose reccomended

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42
Q

cumulative lifetime dose of xrt

A

10msv x age

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43
Q

NEW dose /5 years, / year

A

100mSv/ 5 years
max allowed dose /yr = 50mSv
avg dose should be <20mSv/ yr

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44
Q

whole body dose suring pregnancy

A

4msv / pregnancy

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45
Q

how often should expectant mothers dose be monitored

A

every 2 weeks

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46
Q

what is the contribution of terrestrial xrt

A

typically .5mSV / year

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47
Q

what is the canadian public allowed in terms of XRT /yr

A

1 msv

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48
Q

dose cystits

A

30-40Gy

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49
Q

dose alopecia

A

20Gy

50
Q

what is myelosupression

A
  • in BM function
51
Q

anemia

A
  • RBC (hematocrit or hemoglobin)
52
Q

hematocrit

A

M: 38-46
W: 35-44

53
Q

hemoglobin

A

m: 13-16
w: 12-15
kids: 11-14

54
Q

RBC amounts

A

M: 4.3-5.6
W: 4-5.2

55
Q

platlets normal amount

A

165,000-415,000

<20,000 is very bad

56
Q

total WBC count

A

3500-9050

57
Q

what are the components of WBC

A

Neutophils, leukocytes, monocytes, eosinophils, basophils

58
Q

normal neutrophil amount:

A

60%

59
Q

normal leukocye amount

A

30% 710-4530

60
Q

normal monocytes

A

6% 140-720

61
Q

eosinophils normal amount

A

3% 0-540

62
Q

basophils normal amount

A

1% 0-180

63
Q

WHAT IS leukopnia

A
  • WBC
64
Q

What is thrombocytopenia

A
  • platlets
65
Q

what is pancytopenia

A
  • all lvls : WBC, RBC, platlets
66
Q

what must be done for pt with leukopenia

A

they will have - abilty to fight off infections, they must take prcauion to prevent infection

67
Q

what must be done for pt with thrombocytopenia

A

they have - blood clotting abilities, therefore its important that they dont cut themselves, ensure that they dont harm the gums of their mouthes

68
Q

pharmodynamics

A

th way drugs affet the body

69
Q

pharmokinetics

A

the way drus travel through the body to the required spot

70
Q

iatrogenic disease

A

long term drug use that damages organs ex: secondary cancers orf thrombocytopenia

71
Q

what is hypovolemia

A

it is shock, caused sometims by contrast administaration when too much water is drawn from th vessels

72
Q

what is parenteral drug administration

A

this is when the drug bypasses the GI tract

it is absorbed quickly and efficiently

73
Q

4 subtypes of perenteral admin

A

depends on depth of injection
1- intradermal (shallow)
2- subcutaneous (45-90 degree) injection below surface of skin
3- intramuscular (90

74
Q

which vein is best for drawing blood

A

large antecubital vein

75
Q

what veins are bst for laong term IV sdmin

A

lower cephalic, accesory cephalic, basilic veins

76
Q

blood pressure

A

90-140/ 60-80

77
Q

oral temp

A

36-37 C

78
Q

pulse

A

60-100 bpm

79
Q

when LET + RBE

A

+

80
Q

WHATS the optimal LET

A

100kev/ um

81
Q

radiosensitizers

A

chemicals that enhance response to XRT

82
Q

RADIOPROTECTORS

A
  • cellular rsponse to XRT
83
Q

when are cells most senitive to XRT in the cell cycle

A

G2 and M phase, mid sensitivity in G1, most resistant in S phase

84
Q

when is the most resistant timed in the cell cycle

A

S phase

85
Q

regeneration after EBRT damage organs

A

some organs can be fixed by regeneration
Organs that are repaired this way are made of VIM (vegetative intermitotic) or DIM cells ( differentiating intermitotic)
these organs are: skin, sm intestine, BM

86
Q

rpair after XRT damage

A

is healed by cells of a different organ/ cell type- this causes fibrosis or scar formation

87
Q

what dose is repair most common at

A

doses >1000CGY

88
Q

What organs is repairf most common in

A

radioresistant organs RPM and FPM parenchymal cells that do not divide or have the abiloty to divide (RPM -reverting postmitotic cells ex: liver or FPM- fixed postmitotic cells ex: nerve, muscle, RBC, sperm

89
Q

structually defined FSU and ex

A

when only a predtermined amount of the organ can e replaired

ex: kidney and SC

90
Q

Structurally undefined FSU and ex

A

skin, where cells can migrate through organ and repair damage

91
Q

the 3 acute radiation syndromes as a resultg of whole body exposure

A

hematopoetic syndrome
GI syndrome
cerebrovasculat syndrome

92
Q

what are the phases of the whole body exposure syndrome

A

prodomal stage
latent phase
manifest illness stage

93
Q

who is more resistant to XRT? M vs F old vs young

A

F are more resistant

extremely young and old are more sensitive than mid aged

94
Q

dose and mean dose of hematopoetic syndrome

A

100-1000cGy

mean dose” 350-450cgy

95
Q

hematopoetic syndrome phases s&s and timing

A

latent stage lasts from few days to 3 wks (BM and SCdie)
msnifest illness week 3-5 pancytopenia occurs
<300 pt will survive
300-500 death can occur after 4 wks
500-1000 death can occur in 2 wks

96
Q

COD hemapoetic syndrome

A

infection and hemorhage after BM destruction

97
Q

what dose to GI syndromed occur`

A

1000-10,000cgy

can overlap hematopoetic syndrome at doses as low as 600cgy and with cerebrovascualr syndrome >5000

98
Q

mean survival time gi syndrome

A

3-10 days and as long as 2 wks

99
Q

GI syndrome timing and s&s

A

prodormal hrs after exposure- n&v, darhea and abdo cramps
latent stage2 - 5 days after exposure
manifest illness stage 5-10 days post exposure : n&v, diarrhea and fever

100
Q

COD GI syndrome

A

BM damage leads to infection, dehydration, and electrolyted imbalance

101
Q

what blood level changes occur in GI syndrome

A

-WBC leukocytes

other blood levels dont get a chance to change as pt dies b4 this happens

102
Q

dose for cerebrovascualr damage

A

can occur at doses as low as 5000cgy ->10,000CGY

103
Q

Stages and timing and s&s of cerebrovasular syndrome

A

prodomal stage mins-hrs (nervousness, confusion, n&V, loss of conciousness and burning sensation
latent stage- several hours or less
manifest illness-5-6 hous after exposure diarhea, convulsions, coma and death`

104
Q

what is COD from Cerebrovascular syndrome

A

not well known but thought to be d/t ICP

105
Q

WHATV happens when mother is XRT in 4-11 wks gestation

A

cns and skeletal abnormalities to child

106
Q

what occurs with xrt during week 2-3 gestation

A

high frequency of prenatal death or no effdct at all “ all or nothing effect”

107
Q

what occurs during fetal irradiation after 11-16 weeks gestation

A

mental retardation and microencephaly

108
Q

what occurs during fetal XRT after 20 weeks gestation

A

functional defects like sterility

109
Q

what does stochastic effects mean

A

severity of cancer does nOT depend on dose given, every dose causes some level of risk

110
Q

deterministic effects

A

after a certain dose threshold is exceeded an effect will happen, below this dose the effect will not ocur

111
Q

what cancers are associated with XRT expsoure

A

skin, thyroid, breast, os, lung, leukaemia

112
Q

hyperfractionated

A

BID, TID

113
Q

Hypofractionated

A

> 2Gy / fx

114
Q

4 rs of radibio

A

repair, reoxygenation, redistribution, repopulation

115
Q

OER of x rays and gamma rays

A

2.5-3

116
Q

stochastic vs deterministic in terms of timing

A

deterministic are changes seen within days-weeks

stochastic are effecst seen months- yrs after xposure

117
Q

reference dose of alpha in BED equation

A

alpha denotes the dose for early effects and is 10Gy

118
Q

reference dose beta in BED equations

A

beta denots the dose for late effects and is 3Gy

119
Q

when are radioprotectors/ sensitizers gven in relatio to the timing of tx

A

administer doses within an hour or 2

120
Q

carcinogenesis is deterministic r stochastic

A

stochastic