miscellaneous` Flashcards
irreversible cell changes
cellular death (necrosis) or changes that eventually become lethal to the cell (apoptosis)
what is apoptosis
programmed cell death
extravasation
accidental leakage of iv drugs into tissue either through the weak portion of the vein or because the needle punctured vein and infusion goes directly into surrounding tissue or because needle punctures the vein and the infusion goest directly into the surrounding tissue
most common cause of tissue damage
hypoxia
neoplasia definition
abnormal process that results in the formation of a neoplasm or tumour
4 phases of the dell cycle
G1,S,G2,M
what part of the cell cycle is radio resistant
S Phase, worst part of the cell cycle for XRT to be delivered
what part of the cel phase is radiosensitive
G2-M phase (Mp hase s when PMAT occurs)
free radical definition
highly reactive species with unpaired valance shell electron
ex: h2o = H + OH
direct ionization
occurs more often with _____
considered ____radiations
occurs more often wth densely ionizing XRT (protons alpha particles)
considered high LET XRT
fast electron DIRECTLY ionizes DNA molecule causing damage
indirect ionization
occurs more often when _____
occurs more often with sparsely ionizing XRT (xreays, gamma rays)
causes damage to the DNA molecule from splitting H20
\
RBE
relative biologic effectiveness
atio of biological effectiveness of one type of ionizing radiation relative to another, given the same amount of absorbed energy
stable abberation examples
- result in genetic mix ups leading to mutations but the cell remains viable
ex: translocations and inversion aberrations
unstable abberations examples
aberrations that kill the cell are unstable aberrations
ex: rings, dicentric,s anaphase bridges
most common endpoint for cells response to xrt
reproductive failure
what is interphase death
if death of the cell occurs due to XRT of the G1,G2 and S phase
cellular apoptosis has the involvement of what genes
P53 and BCL2
Most potent radiosensitizer
radio sensitizer enhances cells response to XRT
the most potent radio sensitizer is oxygen
what is OER
oxygen enhancement ratio
it compares the response of cells with radiation in the presence and absence of oxygen
what type of cells are considered to be radiosensitive (organs)
testes and bone marrow, skin
organs that are considered to be radioresistant
liver, muscle, brain and spinal cord
deterministic effects
when tissues have a threshold dose associated with a clinical response
phases from radiation syndromes
- prodromal phase: symptoms correlate to dose and can be go or neurological or both in nature within hrs of exposure
- latent phase: period where victim has no symptoms of exposure few days -3wks after exposure
- manifest ill stage: effects of exposure are evident and correlate with dose(3-5 wks after exposure)
how long does it take for death to occu hemapotic syndromer:
300-500cGy
500-100cgy
<300Cgy patient usually recovers in 3-6 dos
300-500cgY PATIENT DIES 4-6 WEEKS
500-1000Cgy occurs within 2 weeks