oral cavity Flashcards
most common subset of oral cavity cancer
lip
oral cavity cancer is more common in men or women
men
age group most common in oral cavity cancer
55-65
what causes oral cavity cancer
alcohol smoking pipes/ tobacco Plummer Vinison syndrome poor oral hygiene betel nut chewing
subsides or oral cavity cancer
upper and lower lips buccal mucosa hard palate upper and lower gingiva floor of mouth ant 2/3 of the tongue retromolar trigone
lymphatics of the upper lip
rain to the submandibular LN, Periaucular and parotid LN are sometimes involved
Lymphatics of the Lower lip, lower gingiva, oral tongue and buccal mucosa
submandibular and subdigastric LN
What LN do metastatic disease occur in for the oral cavity (excluding LN that are from the tip of the tongue or that cross the mid line
usually occurs in the ipsilateral cervical LN
Which subsides of the oral cavity are most likely to have +LN at presentation
oral tongue and floor of the mouth
nodal involvement incidence and hat LN are involved
LN are rarely involved but nodes involved are most likely submandibular and jugulodigastric LN
distant mets site of the oral cavity
lung is most common
other sites include: maxillary sinus, bone, brain or skin of the face
typical presentation of oral cavity cancers
most commonly a mass, ulcer or patch of thickened white or red patch that persists for 2 or more weeks
white and red patches in oral cancers
presentation of oral cancer
white patches are leukoplakia-are more common than erythroplasia and are less likely to be malignant than erethroplasia they are more likely in lower lip, floor of mouth, buccal mucosa, lateral tongue border and retromolar region.
red patches in the mouth are erethryoplasia- occurs mostly on the floor of the mouth, lateral tongue border and soft palate. The majority of erythroplasia are invasive carcinoma, carcinoma in situ, or severe epithelial dysplasia and must always be regarded as serious. It becomes malignant 50% of the time
oral cavity cancers present )______
early
diagnosis of oral cavity cancer
commonly diagnosed by the careful diagnosis by the dentist or doctor
inspection or palpation
biopsy
TNM of oral cavity cancer
T1-<2cm T2-2-4cm T3 >4cm T4 invading other tissues N1-mets in a single LN <3cm N2-mets in ipsilateral LN 3-6cm N3 mets >6cm
stages or oral cavity cancer
same for all H&N cancers except Nasopharynx stage 1- T1 N0 stage 2 T2 n0 stage 3- T1-T3 N1 stage T3 N0 stage 4 any T, any N M1 T4, any N M0 any T N2,N3 M0
prognostic indicators in oral cavity cancer
stage
location- the further into the oral cavity the worse prognosis therefore lip has the best diagnosis
LN involvement
distant mets
what must be done before XRT in oral cavity cancer
dental visit must be done first and dental surgery and tooth extractions must be done before XRT this helps its to avoid getting osteoradionecrosis, Also careful oral hygiene throughout treatment is important
chemo in oral cavity cancer
chemo is sometimes given concurrently with XRT but is rarely used in oral cavity cancer
primary treatment for T1-T2 oral cavity cancer
primary treatment is surgery for T1-T2
treatment for T3-T4 oral cavity cancer
primary is surgery followed by XRT dose of 60-66Gy(+/-) concurrent chemo if there is +margins or + LN
Older patients get 66/33 and if the tumour is not operable the treatment is 70/30
oral tongue surgery
excision biopsy is not adequate
wide local excision is treatment of choice for lesions that can be excised trans orally for lesions with a 1cm margin
this is hard to achieve for the posterior part of the mobile tongue and can result in difficulty swallowing and speaking
larger tumours are treated with semi or total hemiglossectomy
XRT for oral tongue
Post op XRT is used for larger lesions close or + margins or perineurial invasion also used for + margins initially that are -after excision
T1-T2 treatment of the oral tongue
lesions can be cured by resection especially in older patients
-55-60Gy for microscopic disease (not common)
-60-65 for small posteriorly situated tumours ill defined lesions inaccessible by Surgery
-65-70Gy for exophytic superficial lesions with muscle involvement are amenable to successful treatment of XRT
-70-75Gyfor medium sized moderately advanced tumours T2 tumours of the floor of the mouth
surgical treatment includes partial glossectomy partial mandibulectomy and neck dissection surgery is used for salvage and recurrent disease
T3-T4 treatment of the oral tongue
unlikely to be cured by XRT alone
managed by XRT 50-60Gy (5-6weeks) +surgery
larger T3-T4 tumours get higher doses
XRT techniques for oral tongue
lateral POP Tongue depressed away from palate with bite block
Portal includes submandibular, subdigastric and submental nodes
Submental nodes are especially important to be covered when the lesion is located at the tip of the tongue, ant floor of the mouth or the lower lip
Upper border shaped to give at least 2 cm margin above the dorsum of the tongue and to spare the hard palate and the parotid glands
Post border is designed to be approximately 2 cm behind the sternocleidomastoid muscle
The inf part of the field usually lies at the thyroid notch
With cervical node mets, treatment of level IV or V nodal stations may be indicated, depending on the degree of nodal involvement
If the post chain requires radiation, portals are reduced at 45 Gy to spare the spinal cord
For lower neck (level IV), these nodes are treated through an ant portal with a larynx shield
dose for oral tongue
post op dose is 60/30GyFor close of +ve margins or extracapsular extension in any of the cervical nodal stations, an additional 6 Gy is delivered with reduced fields and concurrent chemo is often administered
Smaller, more anteriorly situated primary lesions in an edentulous (lacking teeth) jaw are most suitable for interstitial implant or intraoral cone radiation therapy as a boost procedure
For an anteriorly situated carcinoma that does not involve the adjacent floor of the mouth or gingival ridge, a boost dose of 25-40 Gy in 10 fx, 5 fx a week by intraoral cone, can be given
floor of mouth surgery
resection of the inner table for tumours that re tethered or fixed to the mandible
advanced lesions of the floor of the mouth due to bone invasion are treated by wide local excision and segmental resection of the mandible followed by reconstruction of the floor and mandible
Very advanced disease involving the floor of the mouth, tongue and mandible and for massive neck disease, the chance of cure with any aggressive treatment is low and is often associated with formidable complications
what timing is XRT given for floor of mouth
XRT is given adjuvantly after surgery due to the negative prognostic factors of floor of mouth cancer
XRT procedure and dose for floor of mouth cancer T3-T4
t3-t4 INVOLVEMENT OF THE TONGUE AND MANDIBLE ARE TREATED PRIMARILY BY radical surgery followed by plastic closure and then adjuvant XRT
lat POP 45Gy for 4-5weeks followed by reduced fields with a total dose of 75-77Gy hypo fractionation 1.2Gy/fx b.i.d.
treatment for very small superficial lesions of the floor of mouth
can be treated with interstitial implant 60-65Gy or intramural cone 45Gy/3 weeks alone
treatment for T1-T2 floor of mouth cancer
treatment is 45Gy EBRT +boost
+interstitial implant of 25Gy
or+ intraoral cone of 20Gy
treatment for small lesions of the lip
small lesions of the lip <2cm
treated with surgery OR radiation in 90% of patients
post op XRT is used for +surgical margins or perineurial invasion
treatment of larger lesions of the lip
larger lesions of the lip are >4cm are treated with radiation with surgery used for salvage treatment