Stomach Flashcards
Pyloric stenosis
presentation
2 wk after birth
olive like mass, visible peristalsis, emesis
Curling ulcer
acute gastritis resulting from severe burns
Differences between acute gastritis and peptic ulcer disease
acute gastritis: acid damage to stomach mucosa
peptid ulcer disease: mucosal ulcer formation
Etiologies of acute gastritis
NOT H PYLORI
shock, NSAIDs, EtOH, chemo, elevated ICP
How does elevated ICP cause an acute ulcer?
elevated ICP causes vagus stimulation
ACh activates secretion of acid at parietal cell
Why are many head trauma patients put on a PPI?
increased ICP cause stimulate CNX
–> hypersecretion of acid from parietal cells
Chronic gastritis basic etiologies
H. pylori and autoimmune gastritis
Autoimmune gastritis etiology
type IV hypersensitivity against parietal cells or IF
Ab formed in the process
can measure anti-parietal cell Ab in serum
Metaplasia that occurs in autoimmune gastritis
intestinal metaplasia
inflammatory cells enter infiltrate stomach
sm intestine has Peyer’s patches –> used to having WBCs
stomach undergoes intestinal metaplasia b/c environment
Presentation of chronic gastritis, common
megaloblastic anemia
damage to parietal cells –> lack of IF
B12 deficiency
How does H. pylori cause inflammation in chronic gastritis
ureases and proteases
Peptic ulcer disease etiologies
H. pylori (most)
Zollinger-Ellison syndrome (few)
Duodenal ulcer presentation
epigastric pain that improves with meals
because eating forces duodenum to produce bicarb and save that ulcer at least a little acid burn
Histo findings of duodenal ulcer
hyperplasia of Brunner glands
Brunner glands make bicarb, should neutralize the acid
Intestinal metaplasia of gastric mucosa refers to what cell switching to what cell
ss –> non-ciliated columnar epithelium w/ goblet cells
