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Ch. 10 GI Pathology > Small Bowel > Flashcards

Small Bowel Flashcards

1
Q

Double bubble sign

A

duodenal atresia
air builds up on either side of the pyloric sphincter
–> double bubble sign

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2
Q

Complications of Meckel

A 
intussusception
hemorrhage (from ectopic gastric tissue)
obstruction
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3
Q

Intussusception causes in
children
adults

A

children: lympoid hyperplasia 2˚ to viral illness
adults: tumor

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4
Q

Currant jelly stools

A

intussusception

due to infarction of affected area

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5
Q

Two types of small bowel infarction

A

transmural: clots
mucosal: hypotension

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6
Q

Congenital lactose intolerance

inheritance pattern

A

recessive

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7
Q

Diarrhea in lactose intolerance

A

osmotic

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8
Q

Celiac

immune reaction against

A

gliadin

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9
Q

HLA subtypes associated with celiac

A

DQ2 and 8

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10
Q

Celiac

what is actually damaged

A

duodenal villi

flattening of duodenal villi

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11
Q

Dermatitis herpetiformis

A

IgA deposition on tips of dermal papillae
vesicle formation
celiac association

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12
Q

Lab tests in celiac

A

IgA against gliadin, tTG, or endomysium

of IgG if pt is IgA deficient

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13
Q

Duodenal Bx in celiac

A

flattening of villi in duodenum

intraepithelial lymphocytes

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14
Q

Complications of celiac

even if well controlled

A

small bowel carcinoma

T-cell lymphoma

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15
Q

Tropical sprue
etiology
damage

A

unknown organism

damages jejunum and ileum after diarrhea

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16
Q

Presentation of Whipple disease
+
pathophys

A

steatorrhea, fat malabsorption
macrophages full of organism T. whippelii
macrophages compress lacteals
chylomicrons cannot be absorbed

17
Q

Abetalipoproteinemia
inheritance
problem

A

recessive
cannot produce ApoB48 and ApoB100
absent plasma VLDL and LDL

18
Q

Carcinoid tumors Sx

A

bronchospasm
diarrhea
flushing of skin
w/ emotional distress or alcohol

19
Q

Main NT in carcinoid tumors

A

5-HT
only active if mets to liver so can get to systemic circulation
MOA also in lungs so damage only occurs through right side of heart
–> tricuspid fibrosis and pulmonary valve fibrosis

20
Q

Carcinoid tumor

metabolites

A

5-HIAA

metabolite of 5-HT

21
Q

Carcinoid tumors

stain

A

chromogranin +

Ch. 10 GI Pathology (8 decks)

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