STIs Flashcards
organisms
very susceptible to drying out
Syphillis
caused by T pallidum (spirochete) 3 stages of disease 1) primary - chancre on penis, painless, swelling of lymph nodes, breakdown of tissue may be undetected in women 2) secondary - occurs at 6-8 weeks if not treated generalised rash/lesions coridylomata lata - highly infectious lesions 3) tertiary (3-30 years) non infectious gummas in 30% of infected CV lesions, meningitis erosion of the skin
diagnosis of syphilis
serological - immune reaction
wont grow in lab
sample from chancre is visualised
Gonorrhoea
gonococal urethritis neisseria gonorrhoea obligate intracellular sex bias: 20% infected women show symptoms 90% infected men show symptoms discharge, burning sensation (same as non-gonococccal urethritis) asymptomatic patients serious symptoms not treated: septic arthritis sterility pelvic inflammatory disease opthalimia neonatium (newborns)
diagnosis of gonorrhoea
VPAT agar - gonorrhea resistant to vancomycin, polymexin, amphoterin and trimethoprim
capnophillic - grows in higher CO2 levels
non specific urethrits = chlamydia = non-gonococcal
chlamydia trachomitis serovars D KK L obligate intracellular commonest UTI incubation 1-3 weeks 80% females asymptomatic 50% of males asymptomatic 10-40% women develop pelvic inflammatory disease can be caused by mycoplasma genetalium can be co infection with gonorrhoea virulence: type 3 secretion
diagnosing chlamydia
nucleic acid amplification test
wont grow on plates
tropical genital ulcerations
lymphogranuloma venerium
serovars L and C of chlamydia trachomatis
infection of lymph nodes
asymptomatic in women
Chancroid
Haemophilus ducroyi
gram negative bacillus
painful chancre
Granuloma Inguinale
localised tissue destruction around penis
erosion
Klebsiella Inguinale
bacterial vaginosis
risk factor: multiple sexual partners
clue cells and ‘whiff test’
reduction in dominant lactobacilli flora
increase in bacteroides
