Stimulants

Question 1

This drug is chemically related to amphetamine.

Answer 1

Methylphenidate

Question 2

Methylphenidate peaks in __-__h and lasts about __

Answer 2

1-3, 6 hours

Question 3

Methylphenidate is used commonly because of:

Answer 3

Better side effect profile

Question 4

Dose range is:

Answer 4

10-60 in 2-3 doses

Question 5

With methylphenidate, the last dose should be taken when to avoid what?

Answer 5

Afternoon to avoid insomnia!

Question 6

To curb anorexia, methylphenidate should be taken:

Answer 6

With meals

Question 7

Sustained release prep can be given:

Answer 7

Once a day

Question 8

Side effects of methylphenidate include: (WARI)

Answer 8

Weight loss
Anorexia
Restlessness
Insomnia

Question 9

Methylphenidate can be potentiated by other:

Answer 9

CNS stimulants including OTC cough/cold meds

Question 10

Methylphenidate and these can cause hypertensive crisis.

Answer 10

MAOI’s

Question 11

T/F Methylphenidate is antagonized by antipsychotics.

Answer 11

TRUE

Question 12

This drug is not commonly used in children under 5.

Answer 12

Dextroamphetamine

Question 13

Oral doses of dextroamphetamine produce results within:

Answer 13

30-60 minutes

Question 14

Half life of dextroamphetamine:

Answer 14

12 hours

Question 15

This speeds excretion:

Answer 15

Urine acidification (cran juice, citrus, VIT C)

Question 16

This slows excretion:

Answer 16

Alkalinization (sodium bicarbonate)

Question 17

Daily dose range, given in.

Answer 17

5-40 in 2 doses

Question 18

May also be given ER…

Answer 18

Once a day

Question 19

T/F dextroamphetamine shares side effects and interactions with methylphenidate.

Answer 19

TRUE

Question 20

This next one, La Lohan’s, is also not used in children under 5.

Answer 20

Dextroamphetamine with amphetamine

Question 21

Daily dose range for adderall:

Answer 21

10-40mg/day

Question 22

Also can be given…

Answer 22

Extended release in AM (20-60mg)

Question 23

WE MUST INFORM PARENTS THAT:

Answer 23

1. Decrease appetite & retard growth
2. Can increase motor/phonic tics or stereotype behaviors.
3. Although they improve attention & reduce hyperactivity, don’t improve interpersonal relationships.
4. Drug holidays may allow child to gain weight & recover slowed growth!

Question 24

Dextroamphetamine causes the greatest:

Answer 24

Growth inhibition

Question 25

In addition to stimulants, we may see:

Answer 25

Non-stimulants

Question 26

This drug is a selective NE reuptake inhibitor, but has shown promise in treating ADHD in children over 6, adol & adults.
(Adam)

Answer 26

Atomoxetine

Question 27

T/F Atomoxetine is well absorbed in GI.

Answer 27

TRUE

Question 28

Atomoxetine is highly protein bound?

Answer 28

YES - Highly

Question 29

Atomoxetine has a half life of…

Answer 29

5-20 hours

Question 30

Atomoxetine is eliminated by the…

Answer 30

Kidneys

Question 31

Total dose range in children is:

Answer 31

0.5mg/kg per day to 1.2mg/kg per day

Question 32

As a selective NE reuptake inhibitor we must not confuse it with:

Answer 32

SNRI (Selective serotonin norepinephrine reuptake inhibitor)

Question 33

Serious side effects include:

Answer 33

Liver damage (rare but serious)
RISK OF SUICIDAL THOUGHTS

Question 34

Other side fx include (8)

Answer 34

Palpitations
Headache/Dry mouth/Dizziness
Constipe/Urinary hesitation/retention
Mood swings
Anorexia

Question 35

Atomoxetine is poteniated by:

Answer 35

Fluoxetine & Paroxetine

Question 36

We can produce this if mixed with MAOI’s.

Answer 36

SEROTONIN SYNDROME