Sedatives, Anxiolytics & Hypnotics - BARBS Flashcards

1
Q

Sedatives, anxiolytics and hypnotics all do what to the CNS?

A

Depress it!

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2
Q

Sedatives, anxiolytics & hypnotics can cause 3 things:

A

Reduction in anxiety
Sedation
Sleep

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3
Q

Sedatives, anxiolytics & hypnotics are commonly used to treat: (4)

A

Anxiety
Panic disorders
Insomnia
OCD

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4
Q

Three groups?

A

Barbiturates
Benzodiazepines
Non-benzodiazepines

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5
Q

These are also used to treat seizure disorders

A

Barbiturates

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6
Q

T/F Barbiturates have been largely replaced by benzodiazepines.

A

TRUE

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7
Q

Barbiturates are often still used in…

A

Pre-operative circumstances

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8
Q

Sedatives, anxiolytics & hypnotics have what common positive characteristics?

A

General calming effect
Redux anxiety & apprehension
Cause drowsiness & induce sleep

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9
Q

In contrast, what common negative effects?

A

Significant potential for abuse
Withdrawal symptoms
Dependence
Affect SYMPTOMS but not PATHOLOGY

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10
Q

T/F Barbiturates are capable of producing all levels of CNS depression from mild sedation to death.

A

TRUE

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11
Q

In the case of death it is usually RT:

A

Respiratory Depression

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12
Q

These drugs depress exicitability of…

A

Pre & Post-synaptic membrane in cerebral cortex & limbic system.

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13
Q

In advance of sleepiness they may produce..

A

Sense excitement & euphoria

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14
Q

Barbiturates ________ motor activity & produce _____ & _______.

A

Decrease, sedation & drowsiness

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15
Q

T/F perception is clear on barbiturates.

A

False - Cloudy

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16
Q

A good nights sleep on barbiturates? Y/N?

A

No - suppress REM sleep

17
Q

Absorbed well in GI tract?

A

Yes!

18
Q

Peak onset ranges from __-__ depending on drug. Fast acting!

A

15-60 minutes

19
Q

Duration may be as long as __-__ hours.

A

10-12

20
Q

If PO not available, barbiturates may be given…

A

Rectally

21
Q

In addition to rectally, available in what preparations?

A

Oral/IM

22
Q

Tolerance of barbiturates develops in…

A

1-2 weeks

23
Q

Trouble with early tolerance is it may lead to..

A

Dependence

24
Q

Short Acting (2) PS

A

Pentobarbital

Secobarbital

25
Q

Intermediate Acting (1) (A)

A

Amobarbital

26
Q

Long Acting (2) MP

A

Mephobarbital

Phenobarbital

27
Q

Side effects of barbs?

A

Extensions of CNS depression

Dizziness, unsteadiness, drowsiness, hangover

28
Q

The higher the barbiturate dose…

A

The higher the risk of side effects!

29
Q

When using barbiturates beware mixing with

A

Other CNS depressants, as can lead to dangerous respiratory depression

30
Q

If on birth control?

A

Barbiturates will decrease effectiveness of estrogen drugs, including oral contraceptives

31
Q

When used with these 2 it causes an increased effect & longer duration of barbiturates.

A

Valproic Acid & Cimetidine