Sedatives, Anxiolytics & Hypnotics - BARBS Flashcards
Sedatives, anxiolytics and hypnotics all do what to the CNS?
Depress it!
Sedatives, anxiolytics & hypnotics can cause 3 things:
Reduction in anxiety
Sedation
Sleep
Sedatives, anxiolytics & hypnotics are commonly used to treat: (4)
Anxiety
Panic disorders
Insomnia
OCD
Three groups?
Barbiturates
Benzodiazepines
Non-benzodiazepines
These are also used to treat seizure disorders
Barbiturates
T/F Barbiturates have been largely replaced by benzodiazepines.
TRUE
Barbiturates are often still used in…
Pre-operative circumstances
Sedatives, anxiolytics & hypnotics have what common positive characteristics?
General calming effect
Redux anxiety & apprehension
Cause drowsiness & induce sleep
In contrast, what common negative effects?
Significant potential for abuse
Withdrawal symptoms
Dependence
Affect SYMPTOMS but not PATHOLOGY
T/F Barbiturates are capable of producing all levels of CNS depression from mild sedation to death.
TRUE
In the case of death it is usually RT:
Respiratory Depression
These drugs depress exicitability of…
Pre & Post-synaptic membrane in cerebral cortex & limbic system.
In advance of sleepiness they may produce..
Sense excitement & euphoria
Barbiturates ________ motor activity & produce _____ & _______.
Decrease, sedation & drowsiness
T/F perception is clear on barbiturates.
False - Cloudy
A good nights sleep on barbiturates? Y/N?
No - suppress REM sleep
Absorbed well in GI tract?
Yes!
Peak onset ranges from __-__ depending on drug. Fast acting!
15-60 minutes
Duration may be as long as __-__ hours.
10-12
If PO not available, barbiturates may be given…
Rectally
In addition to rectally, available in what preparations?
Oral/IM
Tolerance of barbiturates develops in…
1-2 weeks
Trouble with early tolerance is it may lead to..
Dependence
Short Acting (2) PS
Pentobarbital
Secobarbital
