Cocaine/Sedative/Amphetamine Abuse

Question 1

Cocaine comes in 2 forms:

Answer 1

Cocaine hydrochloride

Cocaine base

Question 2

T/F Cocaine hydrochloride is heat stable.

Answer 2

False - not heat stable, diluted with another substance.

Question 3

Cocaine hydrochloride is taken:

Answer 3

Itranasally

IV injection

Question 4

Cocaine base is heat stable. T/F?

Answer 4

True - nearly pure cocaine

Question 5

Which one is crack? Why?

Answer 5

Cocaine base - because of sound it makes when heated.

Question 6

How does one use crack?

Answer 6

Cook it and smoke it! Inhale as absorbs rapidly.

Question 7

Cocaine effects….NT’s

Answer 7

Multiple

Question 8

In theory, psychological effects of cocaine are believed to appear as a result of action on:

Answer 8

Dopamine Receptors

Question 9

So if dopamine receptors are in question, we can treat craving of cocaine use using:

Answer 9

Dopamine Agonists

Question 10

These two old dopamine agonist bitches, keep showing up!

Answer 10

Amantadine & Bromocriptine

Question 11

This one causes release of remaining dopamine from neurons.

Answer 11

Amantadine

Question 12

However, because it is dependent on natural stores, it is:

Answer 12

Only effective while residual stores last

Question 13

Amantadine is most effective in _____ withdrawal.

Answer 13

Early

Question 14

Dose range to relieve craving for several days-weeks.

Answer 14

200-300mg/day

Question 15

Bromocriptine may have an effect similar to..

Answer 15

Narcotic antagonists similar to naltrexone & opioids.

Question 16

Doses of bromocriptine daily of:

Answer 16

0.5-1.5mg to reduce craving

Question 17

IN preventing relapse we may use:

Answer 17

Tricyclics -desi,imi,amitryp

SSRIS

Question 18

We can also use this one for psychosis and these to prevent seizures.

Answer 18

Haloperidol - psychosis

Benzos - seizures

Question 19

Amphetamines are structurally similar to:

Answer 19

NE, E, & D

Question 20

Stimulation of NE, E & D receptors produces an effect similar to:

Answer 20

Cocaine

Question 21

Abusing amphetamines may lead to..

Answer 21

Psychosis

Question 22

To treat psychosis we use:

Answer 22

Dopamine blockers

Question 23

To treat post-wd depression from amphetamines these AD’s are recommended.

Answer 23

Tricyclics

Question 24

Protocols for detox of sedative abuse usually involve:

Answer 24

Substitution of another drug to prevent wd

Question 25

Following stabilization, the substituted drug is reduced how?

Answer 25

Slowly @ 10% per day.

Question 26

Bromocriptine is also useful in treating:

Answer 26

Neuroleptic Malignant Syndrome & Dantrolene too!