Non-benzodiazepines Flashcards
Sleepy one. Mom loves it.
Zopiclone
Zopiclone is most useful for:
Insomnia
Why is zopiclone best for insomnia?
Rapid onset & shorter half-life
Zopiclone works by effecting:
GABA receptors
Abrupt discontinuance after long-term use will produce:
Withdrawal symptoms
Onset of zopiclone?
.5-1hour
Peaks in…
1.5 hours
Half life of around…
5 hours
Dosage of zopiclone? (1-2 tabs) When?
3.75-7.5 @ HS
Zopiclone has odd effects on the mouth including:
Dry mouth
Coated tongue
Bitter, unpleasant taste
Zopiclone can produce this boozy feeling..
Hangover
“I woke up and he was dead officer, I swear”
Zopiclone makes for little memory retention after taking.
Zopiclone interacts with…
Other CNS depressants
The other non-benzo is…
Buspirone
Buspirone is used specifically to treat…
Anxiety
The benefit of Buspirone compared to other benzos is:
NO TOLERANCE RECOGNIZED
LOW POTENTIAL FOR ABUSE & ABSORPTION
T/F Buspirone is useful PRN.
False.
Buspirone produces its maximum anxiolytic effect in…
3-6 weeks
Buspirone is also considered remarkably..
Safe. Can’t OD on it.
Buspirone comes in what preparation?
PO
T/F Buspirone is rapidly absorbed.
TRUE
The patient should be informed to do this before taking.
Eat - increases absorption by reducing first pass metabolism
Peak of buspar?
1-1.5hours
Half-life?
3-11 hours
Buspirone is or is not highly protein bound.
Is highly protein bound.
Dose range for buspirone?
5-30mg/day up to 60mg/day
Side effects of buspirone are..
Minimal but include:
GI upset
Nervousness
Insomnia
Taking buspirone with these will elevate blood pressure.
MAOI
Do not take buspirone with…
Other CNS depressants
