Memory Enhancers in Elderly Flashcards
Dysfunction in memory, especially short-term is RT:
Deficiency in cholinergic function in one part of brain.
And that part would be…
Nuceus Basalis of Meynert
It is suspected that the degeneration of cholinergic receptors is RT
Short-term memory loss in Alzheimers
The progressive spread of this degeneration is also responsible for deficits in (4)
Hearing
Problem solving
Judgment
(Eventual incapacitation)
So in theory, we can slow this progression by _______ levels of ___________.
Raising acetylcholine!
How do we raise acetylcholine levels?
Meds that prevent deactivation of acetylcholine.
Normally, acetlycholine is deactivated by:
Ms. Pac-Man
Acetylcholinesterase
Drugs that inhibit the action of acetylcholinesterase will:
Elevate levels of acetylcholine
When these drugs are used to enhance memory they’re referred to as:
Cognitive Enhancers
Do these drugs cure/prevent Alzheimers?
No - but they can slow the progression. May improve memory in early stages but do not prevent the unfortunate outcome.
Two drugs that are coined cognitive enhancers?
Donepezil
Tacrin
This drug is the first line for improving memory.
Donepezil (Aricept)
Donepezil is a ______ ____-_______ inhibitor of acetylcholinesterase.
Reversible, long-acting
Long or short half life?
Long - once a day dosing
Donepezil is given…
od HS 5-10mg
