Stevens-Johnson Syndrome

Question 1

What is SJS.

Answer 1

A severe form of erythema multiforme and a variant of toxic epidermal necrolysis.

Question 2

What is SJS caused by.

Answer 2

It is caused by a hypersensitivity reaction.

Question 3

What are the usual causes of the hypersensitivity reaction in SJS. (3)

Answer 3

Drugs.
Infections.
Cancer.

Question 4

What drugs can induce SJS. (6)

Answer 4

Salicylates. 
Sulfonamides. 
Penicillin. 
Barbiturates. 
Carbamazepine. 
Phenytoin.

Question 5

What are the features of SJS. (2)

Answer 5

Ulceration of the skin and mucosal surfaces.

Typical target lesions develop (often on the palms or soles with blistering in the centre).

Question 6

What are some systemic symptoms of SJS. (6)

Answer 6

Fever. 
Malaise. 
Arthralgia. 
Myalgia. 
Vomiting. 
Diarrhoea.

Question 7

What is the prognosis for patients with SJS. (3)

Answer 7

Mortality is 5%.
May be severe for the first 10days before resolving over 30days.
Damage to the eyes may persist and blindness can result.

Question 8

What mucosal surfaces are often involved in SJS. (3)

Answer 8

Mouth.
Genital.
Eye.

Question 9

What drugs may cause SJS. (4)

Answer 9

NSAIDs.
Sulfonamides.
Anti-convulsants.
Allopurinol.

Question 10

What infections may cause SJS. (2)

Answer 10

Herpes.

Mycoplasma.