Psoriasis Flashcards
What is the genetic component of psoriasis. (2)
Polygenic susceptibility.
Arthropathy is associated with HLA B27.
What is arthropathy associated with in psoriasis.
HLA B27.
What are some exacerbating factors or psoriasis. (3)
Drugs.
Stress.
Infection.
What drugs can exacerbating psoriasis. (4)
Antimalarials.
Beta-blockers.
Alcohol.
Lithium.
What can a streptococcal sore throat precipitate.
Guttate psoriasis.
What are the subtypes of psoriasis. (4)
Stable chronic plaque.
Guttate.
Erythrodermic.
Pustular.
What are the clinical skin signs of chronic plaque psoriasis. (2)
Salmon coloured silver scaly lesions often involving the scalp, behind the ear.
Predominantly occur on extensor surfaces, but can occur anywhere.
What are the nail signs of psoriasis. (5)
Nail pitting. Onycholysis. Nail dystrophy. Yellow-brown discoloration. Sublingual hyperkeratosis.
What is the Koebner phenomenon.
Psoriatic lesions occur over the sites of trauma.
What can the psoriatic lesions look like. (3)
Plaques.
Nummular (coin-shaped).
Guttate (raindrop-shaped).
What percentage of patients with psoriasis develop psoriatic arthropathy.
1%.
What percentage of the population is affected by psoriasis.
2%.
What is psoriasis.
A common papulo-squamous disorder.
What is psoriasis characterized by.
Well-demarcated, red scaly plaques.
What is the pathogenesis of psoriasis.
The skin becomes inflamed and hyperproliferates at about 10 times the normal rate.
What are the two peaks of onset of psoriasis. (2)
16-22 is common and is often associated with a positive family history.
Late onset peaks at 55-60.
What drugs can make psoriasis worse. (3)
Lithium.
Antimalarials.
Rarely beta blockers.
What are the main aetiologies of psoriasis. (4)
Chronic plaque psoriasis.
Flexural psoriasis.
Guttate psoriasis.
Erythrodermic and pustular psoriasis.
What is the most common type of psoriasis.
Chronic plaque psoriasis.
What percentage of patients with psoriasis will develop arthritis.
5-10%.
What is the most severe types of psoriasis.
erythrodermic and pustular.
What is the condition called with erythrodermic and pustular psoriasis occur together.
Von Zumbusch psoriasis.
