Steroid hormones Flashcards
What are human steroids derived from?
Dietary steroids or made from acetyl-CoA in liver
What is the most abundant steroid?
Cholesterol
What do corticosteroids include?
Glucocorticoids and mineralocorticoids
Where are oestrogen and progesterone made?
Ovary
Placenta during pregnancy
Where is testosterone made?
Testes
Describe the effect of anabolic steroids?
Interact with androgen receptors to increase muscle and bone synthesis
Describe the pathway for the production of cholesterol from acetyl-CoA in the liver?
How are steroids eliminated from the body?
Oxidation by cytochrome P450
Most significant pathway involves CYP3A4 in liver ER
Introduces -OH into steroid ring
Describe how steroids exert their effects on target tissues?
Enter cells > bind internal receptors > steroid-receptor complex binds at Hormone Response Elements in DNA > gene expression altered
Describe the function of the nuclear androgen receptor?
Allows male sex steroids to meidate the male phenotype
What is cyproterone acetate?
What is it used for?
Synthetic steroid inhibitor of androgen receptor > blocks synthesis of mRNA for androgenic proteins
Used to treat hirsutism in females, and as part of hormone therapy for male-to-female gender change
List the steroids released from the layers of the adrenal cortex?
List the secretion signal for each?
Zona reticularis: DHEA (signal is ACTH)
Zona fasiculata: cortisol (signal is ACTH)
Zona glomerulosa: aldosterone (signal is Ang II/III and ACTH)
What is DHEA?
Describe its function?
Testosterone-like
Various protective effects of adrenal cortex
Weak androgen
Which hormones have mineralocorticoid function?
Aldosterone
Progesterone
Deoxycortisone
Describe how mineralocorticoids exert their effects on target tissues?
Bind cytosolic mineralocorticoid receptor > translocate into nucleus > alter gene expression