Steroid Biochem

Question 1

Adrenal Cortex Synthesizes

Answer 1

Corticoids (GC and MC)

Question 2

GC’s are

Answer 2

Cortisol

Question 3

MC’s are

Answer 3

Aldosterone

Regulated by Renin-angiotension system

Question 4

Deficiency is what cause alternations to the corticosteroid synthesis

Answer 4

21 beta and 11 beta

Question 5

21 beta leads to

Answer 5

little mineralcorticoids

lots of androgen

Question 6

11 beta leads to

Answer 6

increased mineralcorticoids activity

- deficiency = cortisol binding to MCR

Question 7

Cortisol binds to

Answer 7

GC receptors and MC receptors (MC activity)

Question 8

Without adrenal cortex,

Answer 8

Stressers (infxn, trauma, temp) could be life threatening

Question 9

GC Actions

Answer 9

Diabetes
Buffalo hump, moon face, truncal fat
Decrease immune response
Prevent or suppress inflammation

Question 10

GC Anti-inflammatory/Immunosuppressed Activity

Answer 10

Reduced lymphocytes, monocytes, and eosinophils
Decreased inflam cells
Inhibit PGs
Impaired ab production

Question 11

MC Actions

Answer 11

Electrolyte and water imbalance

Question 12

Corticosteroids actions

Answer 12

Hypertension
Muscle weakness
Mood, behavior and brain excitability

Question 13

Corticosteroids AE

Answer 13

Suppress HPA