Pharmacology of Thyroid Disease

Question 1

Hypothyroidism Treatment

Answer 1

Replacement

Question 2

Hypothyroidism Drugs

Answer 2

Levothyroxine sodium (7 days half life)
Liothyronine sodium (1.5 day half life & high CV)

Question 3

Hyper treatment

Answer 3

Surgery (rapid but permanent hypo)
Drugs (low cost but adr)
Radioactive iodine (cost effective but permanent hypo)

Question 4

Anti-Thyroid Drugs MOA

Answer 4

Inhiibit iodination and coupling

Question 5

Ionic Inhibitor MOA

Answer 5

Block iodide transportation

Question 6

High conc of iodine MOA

Answer 6

Decrease release of hormones

Question 7

Thyroid Synthesis

Answer 7

Iodine transport
Iodination
Coupling
Colloid Reabsorption
Deiodination of excess
Deodination of T4

Question 8

Anti-Thyroid Drugs

Answer 8

Propylthiouracil
Methimazole (Tapazole)
3-6 weeks for results

Question 9

Ionic Inhibitors

Answer 9

Thiocynate
Perchlorate
Fluoroborate

Question 10

Iodide MOA

Answer 10

Limits its own transport
Inhibits synthesis/release of hormones
Decrease size and vascularity of thyroid

Question 11

Iodide Drugs

Answer 11

Lugol’s solution

SSKI

Question 12

Radioactive Iodine Drug

Answer 12

Hicon

Question 13

Beta Blockers

Answer 13

Propranolo Nadolol
Block HTN, tachycardia
No T4 to T3

Question 14

Hyper treatment

Answer 14

Anions
Propylthiouracil
Methimazole