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Endo Final > Pharmacology of Pituitary Disorders > Flashcards

Pharmacology of Pituitary Disorders Flashcards

1
Q

Negative Feedback of GH

A

GH and IGF-1

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2
Q

Decrease GH synthesis

A

Beta agonists

FFA

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3
Q

Stimulate GH synthesis

A

Ghrelin
DA
Serotonin
Agonists

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4
Q

GH MOA

A

Membrane Receptors –> regulate gene expression

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5
Q

Excess of GH

A

Acromegaly in adults

Gigantism in children

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6
Q

Treatment GOALS of Excess GH

A

Reduction in GH and IGF-1

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7
Q

Excess GH Treatment

A

Surgery
Radiation
Adjuvant pharmco (Somatostatin analogs, GH receptor antagonist, dopamine)

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8
Q

Somatostatin Analogs MOA

A

Bind SSTR2/5 and block GH secretion

Work in the pituitary and stop release

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9
Q

Somatostatin Analog drugs

A

Ocrreotide (sandosatin)
Lanreotide (Somatuline
Both injections

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10
Q

GH Antagonists

A

Pegvisomant (somavert)
Decrease IGF-1 levels
Block GH action

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11
Q

Dopamine Agonists

A

Bromocriptine

Decrease GH production via pituitary

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12
Q

HypoGH treatment

A

Increase GH
Replace GH
Provide IGF-1

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13
Q

GH Replacement therapy

A

Rocombinant GH
Not used any longer
Somatropin or Somatrem (SQ)

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14
Q

GH Replacement therapy AE & Interactions

A

Leukemia
Estrogen
Adrenal insuff

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15
Q

Recombinant IGF-1

A

Increlex or Iplex

SQ

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16
Q

Hyperprolactinemia Treatment Options

A

Surgery
Radiation
Discontinue med causing it
Dopamine agonists

17
Q

Dopamine Agonists MOA

A

Inhibit release and decrease tumor size

18
Q

Dopamine Agonist Drugs

A

Bromoriptine (Parlodel)
Cabergoline (dostinex)
Pergolide (Permax)

19
Q

Cabergoline/Dostinex Special Property

A

Long half life

Dose adjust in hep failure

20
Q

Drugs that are NOT injection

A

Bromocriptine

Pergolide

Endo Final (10 decks)

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