Pharmacology of Pituitary Disorders Flashcards
Negative Feedback of GH
GH and IGF-1
Decrease GH synthesis
Beta agonists
FFA
Stimulate GH synthesis
Ghrelin
DA
Serotonin
Agonists
GH MOA
Membrane Receptors –> regulate gene expression
Excess of GH
Acromegaly in adults
Gigantism in children
Treatment GOALS of Excess GH
Reduction in GH and IGF-1
Excess GH Treatment
Surgery
Radiation
Adjuvant pharmco (Somatostatin analogs, GH receptor antagonist, dopamine)
Somatostatin Analogs MOA
Bind SSTR2/5 and block GH secretion
Work in the pituitary and stop release
Somatostatin Analog drugs
Ocrreotide (sandosatin)
Lanreotide (Somatuline
Both injections
GH Antagonists
Pegvisomant (somavert)
Decrease IGF-1 levels
Block GH action
Dopamine Agonists
Bromocriptine
Decrease GH production via pituitary
HypoGH treatment
Increase GH
Replace GH
Provide IGF-1
GH Replacement therapy
Rocombinant GH
Not used any longer
Somatropin or Somatrem (SQ)
GH Replacement therapy AE & Interactions
Leukemia
Estrogen
Adrenal insuff
Recombinant IGF-1
Increlex or Iplex
SQ
Hyperprolactinemia Treatment Options
Surgery
Radiation
Discontinue med causing it
Dopamine agonists
Dopamine Agonists MOA
Inhibit release and decrease tumor size
Dopamine Agonist Drugs
Bromoriptine (Parlodel)
Cabergoline (dostinex)
Pergolide (Permax)
Cabergoline/Dostinex Special Property
Long half life
Dose adjust in hep failure
Drugs that are NOT injection
Bromocriptine
Pergolide
