Stem Cell Theory of Hematopoiesis Flashcards
All cells are derived from a pool of stem cells that are
self-renewing
give rise to committed stem cells for each line
Pluripotential and multipotential stem cells
T/F. Committed stem cells have receptors for specific growth factors
True
Respond to stimulation by division and maturation (precursor cell stages) into
end-stage cells
T/F. In healthy individual, only immature/immature RBCs are seen in the peripheral
False, only mature/mature RBCs
Hematopoietic cells originates from common cell which is the
Pluripotent Stem Cell
PSC will be divided into:
(which are also the category of leukemia)
Lymphoid stem cell and Myeloid stem cell
seen on Hodgkin’s and Non-hodgkin’s
Lymphoid Cancer
happens few hours after the fertilization of ovum → will be develop into any cell type → fetus
Totipotent
develops after several days → will be develop into any cell type but not a fetus
Pluripotent
will be found in the BM, Neural SC, Muscle SC, Liver SC
Multipotent
major regulator of erythropoiesis, stimulates erythroid CFU cells and proerythroblasts
Erythropoietin (EPO)
increases platelet production, stimulates megakaryocytes CFU cells
Thrombopoietin (TPO)
increases production of neutrophils, stimulate granulocyte-macrophage CFU cells
Granulocyte CSF (G-CSF)
increases macrophage production, stimulates granulocyte-macrophage CFU cells
Granulocyte-Macrophage CSF (GM-CSF)
stimulate B-and T-cell formation, function together with G-CSF and GM-CSF; produces by wide variety of cells and most of them are glycoproteins
Interleukins
CFU
Colony Forming Unit
CSF
Colony Stimulation Factor
molecules secreted to give signals to other cells
Cytokines (G-CSF, GM-CSF, Interleukins)
pro-protein
Precursors
The circulatory system is made up of blood vessels and endothelium. These are the pathways where blood goes
Blood Vessels
carries high oxygen content from the lungs → send away from the heart to the body
Arteries
4 iron = __ oxygen
4
low O2 from the body to the heart → to reoxygenate in the lungs
Veins
small blood vessels that connects arteries to capillaries
Arterioles
small blood vessels that connects capillaries and veins
Venules
tiny blood vessels that contains blood components and connects arterioles and venules
Capillaries
Thin layer of cells that lines the interior surface of blood vessels and forms the physical and biological barrier.
Endothelium
Responsible for primary and secondary hemostasis to stop or prevent hemolysis
Endothelium
innermost layer, made up of squamous endothelium
Tunica Intima
middle layer, made up of smooth muscle and elastic fibers
Tunica Media
outermost layer, made up of connective tissues
Tunica Externa or Adventitia
