Hematopoiesis

Question 1

Continues regulated process of blood production including the renewal, proliferation, differentiation and maturation

Answer 1

Hematopoiesis

Question 2

Formation, development and specialization of all functional blood cells and its components

Answer 2

Hematopoiesis

Question 3

Blood cells are released from the

Answer 3

bone marrow

Question 4

Bones responsible in the formation of blood cells:

Answer 4

Long bones

Question 5

Hematopoiesis starts during the time of conception

Answer 5

(union → proliferation → totipotent → pluripotent → multipotent → formation of cells)

Question 6

Most hematopoiesis are erythroid (RBC)

Answer 6

Prenatal Hematopoiesis

Question 7

19th day of gestation (2nd week of fetal life) formation of blood islands in yolk sac (mesodermal extraembryonic layer), aggregation of primitive cells

Answer 7

Mesoblastic Period

Question 8

chief site of mesoblastic period

Answer 8

Yolk sac

Question 9

future blood vessels

Answer 9

Angioblast

Question 10

produces measurable amount of hemoglobin that happens intravascularly

Answer 10

9th week of fetal life, development of primitive erythroblast (PE)

Question 11

Enumerate the Three embryonic forms of hemoglobin:

Answer 11

o Gower I
o Gower II
o Portland

Question 12

4 to 5 gestational weeks (stars in the 2nd month) which happens extravascularly

Answer 12

Hepatic Period

Question 13

chief site; 3rd month of fetal life

Answer 13

Liver

Question 14

Recognizable clusters of developing erythroblast, granulocytes, and monocytes

Answer 14

Liver

Question 15

Lymphoid cells already appear

Answer 15

Liver

Question 16

First organ to fully develop in the fetus, major site of T cell production (cellular)

Answer 16

Thymus

Question 17

B cells produced in (humoral cells)

Answer 17

Kidney and spleen

Question 18

Spleen-active in:

Answer 18

• Erythropoiesis
• Myelopoiesis
• Lymphopoiesis

Question 19

Spleen-active (until the end of normal gestation (splenic)

Answer 19

Erythropoiesis

Question 20

Spleen-active (becomes minimal by the 5th month)

Answer 20

Myelopoiesis

Question 21

Spleen-active (that is lifetime)

Answer 21

Lymphopoiesis

Question 22

During the Hepatic Period these blood components are produced

Answer 22

NRBC’s, Granulocytes, Monocytes, Lymphocytes and Megakaryocytes

Question 23

Enumerate the Hemoglobin/s produced during the Hepatic Period

Answer 23

o Hb A
o Hb A2
o Hb F

Question 24

also developed during hepatic period

Answer 24

Lymph nodes

Question 25

Starts on the 5th month of fetal life

Answer 25

Medullary/Myeloid Period

Question 26

chief site; occurs in the medulla/inner part of the bone cavity

Answer 26

Red bone marrow

Question 27

Development of cells increases at birth

Answer 27

Medullary/Myeloid Period

Question 28

will migrate to the core of the bone (embryonic tissue) → differentiate into skeletal and hematopoietic blood cells

Answer 28

Hematopoietic Stem Cells (HSCs) and mesenchymal cells

Question 29

Hematopoietic Stem Cells (HSCs) and mesenchymal cells will migrate to the core of the bone (embryonic tissue) → differentiate into

Answer 29

skeletal and hematopoietic blood cells

Question 30

Myeloid to erythroid ratio in the 21st week of gestation

Answer 30

3:1

Question 31

What months/ weeks does the bone marrow (shaft of long bones) will be the main site?

Answer 31

By the 6 month/24 weeks of gestation

Question 32

By the 6 month/24 weeks of gestation

Answer 32

bone marrow (shaft of long bones) is the main site

Question 33

begins to appear and gradually increases in concentration

Answer 33

HB A1

Question 34

During Medullary/Myeloid Period these (hormone/ growth factor/hemoglobin) becomes measurable and determined

Answer 34

EPO, G-CSF, GM-CSF, Hb F, Hb A2