Stages of Hematopoiesis

Question 1

Enumerate the types of Hematopoiesis

Answer 1

• Prenatal Hematopoiesis
• Adult Hematopoiesis
• Extramedullary Hematopoiesis

Question 2

Enumerate the Prenatal Stages of Hematopoiesis

Answer 2

1. Totipotent
2. Pluripotent
3. Multipotent

Question 3

happens right after the ovum fertilized, first few hours there’s a development of mesoblastic stage

Answer 3

Totipotent

Question 4

development of embryo to fetus

Answer 4

Totipotent

Question 5

HSCs become present several days after fertilization

Answer 5

Pluripotent

Question 6

development of any cell types except they cannot develop in fetus

Answer 6

Pluripotent

Question 7

derived from the pluripotent stem cells and limited only to specific cells that forms tissue

Answer 7

Multipotent

Question 8

Bone marrow restricted (long bones are responsible to blood production)

Answer 8

Adult Hematopoiesis

Question 9

Bone marrow is made up of

Answer 9

osteoblast and osteoclast

Question 10

(bone-forming cells)

Answer 10

osteoblast

Question 11

(bone-resorbing cells)

Answer 11

osteoclast

Question 12

Is the only site of erythropoiesis, myelopoiesis, thrombopoiesis and lymphopoiesis

Answer 12

Bone Marrow

Question 13

a delicate balance exist between developing bone marrow space trabecular bone and the developing infant’s need for blood cells and liver or spleen remains available because of its hematopoietic capability

Answer 13

1st year of life

Question 14

rate of bone marrow growth exceed the need for blood cells therefore, active marrow sites are replaces with areas of fatty reserve and fat first develops in the long bones (5-7 years old adipose tissues become more abundant)

Answer 14

4th year of life

Question 15

process of replacing the active marrow by the adipose tissue

Answer 15

Retrogression

Question 16

T/F. active yellow marrow will scattered and will be capable of reverting back again to red marrow in case of increased demand

Answer 16

True

Question 17

the only active hematopoietic sites are in the pelvis,
vertebrae, ribs, scapulae, sternum, skull and proximal extremities of the long bones

Answer 17

18th year of life

Question 18

Contains developing erythroid, myeloid, and megakaryotic

Answer 18

Bone Marrow

Question 19

located in the cavities of the cortical bones

Answer 19

Bone marrow

Question 20

Cortical bones cavities consists of

Answer 20

trabecular bone (honey comb)

Question 21

Types of Bone marrow:

Answer 21

RED MARROW
YELLOW MARROW

Question 22

Site of blood cell development

Answer 22

RED MARROW

Question 23

Hematopoietically active bone

Answer 23

RED MARROW

Question 24

Comprises appro. 50% of the marrow/cavity space

Answer 24

RED MARROW

Question 25

Hematopoietic sites are sternum, skull, scapular, vertebrae, ribs, pelvic bones and proximal ends of long bones (adult)

Answer 25

RED MARROW

Question 26

Hematopoietically inactive bone

Answer 26

YELLOW MARROW

Question 27

Mix up of adipose cell (adipocytes), undifferentiated mesenchymal cells and macrophage

Answer 27

YELLOW MARROW

Question 28

T/F. RED AND YELLOW marrow should have approximately unequal amounts

Answer 28

False, must equal amounts

Question 29

develops in the embryo by the hollowing out of the skeletal bones forming a central cavity

Answer 29

Bone marrow

Question 30

In this cavity develops a primitive, undifferentiated cell known as

Answer 30

hemocytoblast or stem cell

Question 31

T/F. All blood formed elements ultimately develop from this undifferentiated precursor

Answer 31

True

Question 32

Full developing precursor cells in all stages of

Answer 32

maturation

Question 33

Released into blood at maturity

Answer 33

Bone marrow

Question 34

T/F. ONLY mature cells are released normally in Bone marrow

Answer 34

True

Question 35

First recognizable precursor in each cells is a

Answer 35

blast

Question 36

requires Peripheral Blood Smear in order to see young cells

Answer 36

Leukemia

Question 37

due to resorption of cartilage and endosteal bone

Answer 37

Central space

Question 38

red marrow are active in:

Answer 38

Infancy and Early Childhood

Question 39

adipocytes are more abundant in:

Answer 39

5 – 7 years old

Question 40

the process of replacing the active marrow by the adipose tissue during development

Answer 40

Retrogression

Question 41

• Bone marrow and thymus
• Where T and B cells are derived

Answer 41

Primary Lymphoid tissue

Question 42

Lymphoid become competent, consist of the spleen and lymph nodes and gut associated lymphoid tissue

Answer 42

Secondary Lymphoid tissue