Extramedullary Hematopoiesis Flashcards
Blood cell production in hematopoietic tissue other than the bone marrow
Extramedullary Hematopoiesis
Principally occurs in liver and spleen (just like in fetus) lymph nodes and thymus
Extramedullary Hematopoiesis
mediate the progenitors and binding to stroma
Proteoglycan or glycosaminoglycans
Enumerate the Adhesion molecules:
o Fibronectin
o Collagen
o Laminin
o Hemonectin
o Thrombospondin
develop during Second trimester
LIVER
Major site of blood cell production during the hepatic stage
LIVER
Storing essential mineral and vitamins that are used in synthesis of DNA and RNA
LIVER
T/F. Liver synthesizing various transport proteins
True
Conjugating bilirubin from
hemoglobin degradation
degradation product of hemoglobin
Stercobilin, urobilin, urochrome
Transporting bilirubin to the small intestine for eventual excretion via
stool and urine
Liver has __ lobes
2
Optimal for gathering, transferring and eliminating substance via the
bile
macrophages in liver cells; removes cellular and foreign debris that circulate throughout the blood
Kupffer cells
phagocytic cells that removes foreign blood materials
Macrophages
allows plasma to have direct access to the hepatocytes
Epithelial cells
Largest lymphoid organs
SPLEEN
SPLEEN’s Primary functions
lymphopoiesis, phagocytosis
Reticuloendothelial organ
SPLEEN
Graveyard of old blood
SPLEEN
absorbs dead RBCs
SPONGE
Life span of RBC
120 days
Located in the left side of the abdomen just below the diaphragm and behind the fundus of the stomach
SPLEEN
T/F. SPLEEN is Vital and essential
False, Vital but not essential
Indiscriminate filter of the circulating blood
SPLEEN
indication of 350mL of blood in SPLEEN
HEALTHY
Organs of the lymphatic system located along the lymphatic capillaries
LYMPH NODES
Bean-shaped structure
LYMPH NODES
Oval structures distributed throughout the body connected by lymphatic vessel which carry a fluid called
lymph
Act as filters to removed foreign blood contaminants. Extremely important part of the body’s infection defense
LYMPH NODES
inguinal, axillary, cervical, and supratrochlear
Superficial LYMPH NODES
mesenteric and retroperitoneal
deep LYMPH NODES
Consist of an outer capsule that forms
trabeculae
Provides support for macrophages predominant population of lymphocytes
LYMPH NODES
Responsible for normal development of some lymphocytes
THYMUS
THYMUS Located in the
neck
T/F. Maximum development in childhood, atrophies with age, bigger in adult
False, Bigger in children
