STD's Flashcards
Nisseria Gonorrhea- resovoir
humans
N. Gon- trasmission
sexual
N. Gon- morphology
Gram negative diplococci
kidney bean shaped
N. Gon- metabolism
Facultative anaerobe that grows best in high CO2 environment.
Glucose only fermenter
N. Gon- virulence factors
Pilli- adherence to epithelial cells. undergo extensive antigenic variation. Antiphagocytic
IgA proteases
Outermembrane proteins- protein I and protein II- Opacity protein
chealators
N. Gon- toxins
endotoxin- LPS
N. Gon- clinical presentation in men
Asymptomatic
Urethritis
N. Gon- clinical presentation in female
cervical gonorrhea –> PID
complications of PID
sterility ectopic pregnancy abscess periotonitis perihepatitis
N. Gon clinical complications n in both sexes
gonococcal bacteremmia
Septic arthritis- MCC of septic arthritis in sexually active individuals
N. Gon- clinical presentation in neonates
Acquired while passing through the birth cananl
Conjuctivits in the 1st 5 days- Opthalmia neonatorum
N. Gon tx- adult- 1st line
3rd gen Cephalosporin- Ceftriaxone
may add doxycycline to cover chlamydia and syphillis
N. Gon tx- adult- 2nd line
Fluroquinolones and Spectinomycin
neither is effective against syphillis
N. Gon tx- opthalmia neonatorum- prophylaxis
Erythromycin eye drops should be given as prophylaxis at birth to protect from N. Gon and chamydia.
N. Gon tx- opthalmia Neonatorum
systemic tx with ceftriaxone
concurrent Erythromycin to cover chlamydia
N. Gon- dx
Gram stain of pus
Culture
PCR
N. Gon- what do you see on gram stain
urethral pus shows diplococci within WBC
N. Gon- culture media
Choclate agar
Thayer Martin VCN
cytochrome oxidase-= pink colonies
N. Gon- immunity
can be reinfected numerous times
Gardinella Vaginallis- transmission
STD
G. Vaginallis- virulence
no capsule
G. vaginallis- toxins
none
G. vaginallis- disease
bacterial vaginitis
Ssx bacterial vaginitis
foul smelling (fishy) vaginal discharge
vaginal pruritis
dysuria
G. Vaginalis- tx
Metronidazole
G. Vaginallis- dx
clue cells
no lacto bacilli
What are clue cells
vaginal epithelial cells with tiny pleomorphic gram negative bacilli in the cytoplasm
G. Vaginallis- growth requirements
DOES NOT required factor X or factor V for growth
Chlamydia trachomatis- reservoir
humans
Chlamydia- morphology
Gram negative BUT lacks peptidoglycan and muramic acid
Chlamydia transmission
contact
Chlamydia- primarily effects what organs
Eyes
Genitals
Lungs
Chlamydia- global distribution
trachoma is mostly found in the under developed word, and transmission is via poor hygiene.
Chlamydia- Life cycle
Elementary body- dense spherule that infects cells –> trans forms to initial body –> when it is ready to leave the cell transforms back to EB to infect other cells
Chlamydia- characteristics of the IB
larger and more osmotically fragile
reproduces via binary fission
requires ATP from host
Chlamydia- metabolism
obligate intracellular parasites b/c it steels ATP from from host via- ATP/ADP translocator
Chlamydia-virulence factors
resistant to lysozymes
prevents phagosome- lysosome fusion
Chlamydia- clinical presentation- types A,B, and C
Trachoma- leading causing of blindness worldwide.
causes scarring of the inside of the eyelid –> redirection of eyelashes onto the corneal surface –> secondary infections cause blindness
Chlamydia- clinical presentation- types D-K- infants
inclusion conjuctivitis (opthalmia neonatorum) infant pneumonia