Clostridium tetani

Question 1

Clostridium Tetetani- micro

Answer 1

G+, bacilli
ubiquitous
highly resistant endospore
Anaerobe

Question 2

Costridium tetanus- toxin

Answer 2

2 subunits

replicates in body

Question 3

Clostridium tentanus- MOA

Answer 3

Exotoxin blocks inhibitory nerves –> spasms

Question 4

Clostridium tetanus- Dx

Answer 4

Hs
clinical
mouse anti-toxin neutralization

Question 5

Clostridium tetanus Immunity-

Answer 5

No Ab are formed after exposure, so one exposure doesn’t protect from future infection

Question 6

Clostridium Tetanus- prevention

Answer 6

Toxoid vaccine causes–> ab production that lasts 10 ysneed boosters

Question 7

Clostridium tetanus- tx

Answer 7

Stop toxin production
anti toxin
control muscle spasms
manage dysautonomia
supportive care for breathing

Question 8

Clostridium tetanus is seen in what populations

Answer 8

Poor wound care
Elderly
poor hygiene or childcare

Question 9

Clostridium tetanus- what time of yr

Answer 9

Summer

Question 10

Clostridium tetanus symptoms

Answer 10

stiffness
cramping
difficulty chewing or swallowing
trismus/ lock jaw

Question 11

Clostridium tetanus- How many types

Answer 11

Generalized
Localized
cephalic
Neonatal

Question 12

Clostridium tetanus- generalized

Answer 12

Most common- 80%
reflex spasms to light and noise 
risus sardonicus- grimmaced face
opisthotonus- arched back
This leads to respiratory failure, aspiration, and generalized exhaustion

Question 13

Clostridium tetanus- localized

Answer 13

spasm at wound site

can progress to generalized

Question 14

Clostridium tetanus- cephallic

Answer 14

head wound
rare
affects cranial nerves leads to generalized

Question 15

Clostridium tetanus- neonatal

Answer 15

severe generalized tetanus in neonates with unimmunized mothers, non sterile birth.
HIGH MORTALITY