SSRIs and St. Johns Wort Flashcards
serotonin syndrome common symptoms?
delirium, agitation, sweating, myoclonus, shivering, coarse tremors, extensor plantar, increased muscle response.
severe cases of serotonin syndrome
hyperthermia, seizures, rhabdomyolysis, renal failure, cardiac dysrhythmias, DIC
SSRI drug name
fluoxetine, Prozac
two facts about SSRIs?
first line for depression and safer than other antidepressants.
contraindications for fluoxetine?
MAOIs, St. Johns wort.
TCAs, warfarin, digoxin, diazepam.
which drug increases the therapeutic effects of fluoxetine?
TCAs
fluoxetine potentiates which drugs?
warfarin, digoxin, diazepam.
takes how long for the full effect of SSRIs?
4-6 weeks
washout when changing classes of meds takes about how long?
2-5 weeks
prozac urges you to monitor which organ function?
liver
(because of the PROtein)
what is a major nursing consideration for SSRIs?
suicidal ideation.
CNS side effects of fluoxetine?
tremors, anxiety.
headache, drowsiness
GI side effects of fluoxetine?
changes in taste, n/v, weight gain.
GU side effects of fluoxetine?
sexual dysfunction, cystitis, urinary retention, painful menstruation.
why is painful menstruation ironic with fluoxetine?
it is used to treat PMDD
St. Johns wort is also called what?
herbal prozac
do not take which antidepressant for more than how many weeks together with St. Johns wort?
MAOI, 2 weeks.
all the contraindications for St. John’s Wort
everything on the left side of the board except…
benzodiazepines, tyramine foods, TCAs, and anticonvulsants.
(lithium is the exception)
anticonvulsants can’t be with which drug/herbal product?
St. John’s wort
further St. John’s wort contraindications
war is SAD- so pray to St. John, he’ll take away everything that is hurting you.
warfarin, statins, digoxin, anticoagulants.
side effects of St. Johns wort
F, D, C, P, H_N
fatigue, dizziness, confusion, photosensitivity, hypertension,
