Antacids and PPIs Flashcards
antacids will only do what to the gastric acid?
neutralize it
calcium carbonate is what
tums
indications for tums
reduction of acid-related pain, pH raised a point in gastric acid, increase in stomach lining protection against irritation.
increase in tone of cardiac sphincter.
Calcium carbonate can cause what, which is why they add what to TUMs
constipation, Mg
antacids will do what to other drugs?
decrease their absorption
many antacids have what?
simethicone
long-term antacid administration can do what?
mask malignancies like ulcers.
three side effects of antacids
hyperacidity rebound, constipation, kidney stones from the calcium.
contraindications of antacids
severe renal failure or electrolyte disturbances.
GI obstructive process
warfarin (their effects are lessened by antacids)
antacids produce what that inactivates other drugs?
chelates, insoluble complexes.
omeprazole is indicated for what
GERD, erosive esophagitis, short-term treatment of active duodenal and benign gastric ulcers, Zollinger-Ellison Syndrome, NSAIDs, and their ulcers.
-stress ulcer prophylaxis
-treatment of H. pylori induced ulcers
all PPI contraindications
increased diazepam and phenytoin
warfarin with an increased chance of bleeding.
absorption of ketoconazole, ampicillin, iron salts, and digoxin.
clopidogrel
sucralfate- shouldn’t take two gastric protectants.
food may decrease absorption
side effects of PPIs
possible predisposition to C. diff, osteoporosis and risk of bone fractures in long term users.
pneumonia
depletion of magnesium
dementia, SLE link with PPIs (also linked to osteoporosis and low magnesium)
antacids and PPIs will both reduce which drug?
warfarin
