HMG-CoA Reductase inhibitors

Question 1

simvastatin is indicated in LDL higher than ______ mg/dL
diabetic pts aged (____ to ____) and with LDL levels around ____ to _____

Answer 1

190, 40-75, 70-189

Question 2

list all the meds contraindicated in simvastatin.

Answer 2

• oral anticoagulants
• erythromycin, cyclosporine, gemfibrozil, niacin. (Ethan craves greasy fried nuggets)
• azole antifungals
• verapamil, diltiazem, amiodarone, digoxin. (very delicious DAiry Queen)
• HIV protease inhibitors
• grapefruit juice

Question 3

side effects of simvastatin

Answer 3

headache
myopathy–>rhabdomyolysis
GI disturbances
Cataracts
insOmnia
fAtigue, flAtulence
liveR disease and increased liver enzymes.
Increased risk for diabetes

Question 4

is rhabdomyolysis reversible?

Answer 4

with discontinuation of simvastatin

Question 5

take simvastatin when?

Answer 5

once at bedtime, or at evening meal.

Question 6

simvastatin is considered?

Answer 6

first line drug, most potent LDL reducer.

Question 7

patient should report what?

Answer 7

muscle soreness or changes in urine color