SRH and early pregnancy Flashcards

1
Q

failure of IUCD - how many women become pregnant within first year?

A

6/1000 perfect use 8/1000 typical use

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2
Q

failure of IUCD - how many women become pregnant within 5 years?

A

1-2/100

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3
Q

risk of IUCD expulsion

A

1/20

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4
Q

risk of uterine perforation with IUCD

A

up to 0.2%

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5
Q

risk of ectopic pregnancy with IUCD

A

1/20

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6
Q

desogestrel: missed pill

A

taken up to 12h later, ie within 12h of time pill was taken on preceding day (36h total)

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7
Q

norethisterone: missed pill

A

taken within 3h of time pill was taken on preceding day (27h total)

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8
Q

levonorgestrel: missed pill

A

taken within 3h of time pill was taken on preceding day (27h total)

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9
Q

POP: failure rate with perfect use

A

3/1000

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10
Q

Implant: failure rate

A

0.05% with typical use

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11
Q

implant: how many will have amenorrhea

A

1/5 (20%)

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12
Q

implant: how many will discontinue due to heavy or irregular bleeding

A

1/5 (20%)

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13
Q

TOA: poor prognostic factors associated with lack of response to medical treatment

A

size of abscess >5cm Age >40 Higher initial white cell count Smoking

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14
Q

female condoms: effective % with correct use vs typical use

A

95% correct use vs 79% Typical use (failure 21% )

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15
Q

male condoms: effective % with correct use vs typical use

A

98% correct use vs 82% typical use

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16
Q

diaphragm/cap: effective % with correct use

A

92-96% Should not be used during menstruation Spermicide reapplied if in situ >3h Do not remove until 6h from last intercourse

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17
Q

incidence of ectopic pregnancy

A

11/1000

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18
Q

maternal mortality rate for ectopic pregnancy

A

2/1000

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19
Q

complete molar pregnancy

A

abnormal diploid (androgenic: empty ovum + haploid sperm, XX) absence of fetal parts snowstorm appearance

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20
Q

partial molar pregnancy

A

3/1000 abnormal triploid (ovum + 2 sperm) fetal tissue present focal villous hydros and cystic spaces, increased AP diameter

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21
Q

risk of molar recurrence after x1

A

1/80

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22
Q

risk of molar recurrence after x2

A

20%

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23
Q

incidence of GTD

A

1/714 pregnancies

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24
Q

incidence of GTN

A

1/50 000 pregnancies

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25
Q

choriocarcinoma present in ___% of molar pregnancy

A

3% (1/40)

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26
Q

hyperemesis definition

A

1) protracted N/V 2) weight loss >5% 3) dehydration 4) electrolyte imbalance

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27
Q

hyperemesis incidence

A

0.2-3.6% (vs. NVP up to 80%)

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28
Q

progestogens associated with LOWEST risk of VTE (5-7/10 000)

A

norethisterone Norgestimate LNG

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29
Q

progestogens associated with INTERMEDIATE risk of VTE (6-12/10 000)

A

etonogestrel norelgestromin

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30
Q

progestogens associated with HIGH risk of VTE (9-12/10 000)

A

drosperinon desogestrel gestodene

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31
Q

cervical cap use

A

insert just before intercourse remove after 6

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32
Q

incidence of ectopic pregnancy

A

11/1000

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33
Q

USS features suggestive of ectopic

A

free peritoneal fluid complex of homogenous adnexal mass adnexal gestation sac with or without fetal pole/FHB tubal ring sign

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34
Q

uSS TV threshold

A

hCG 1000

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35
Q

FN rate of laparoscopy for ectopic diagnosis

A

3-4.5%

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36
Q

definition of ectopic according to NICE

A

adnexal mass moving separate to ovary with gestational sac +/- yolk sac +/- fetal pole

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37
Q

definition of probable ectopic according to NICE

A

adnexal mass moving separate to ovary with an EMPTY gestational sac (bagel sign, tubal sign) or complex inhomogenous mass

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38
Q

definition of possible ectopic according to NCIE

A

empty uterus or pseudosac

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39
Q

criteria for conservative management of tubal ectopic

A

1) clinically stable, pain free 2) <35mm (NICE) 3) bHCG <1000 (NICE) 4) no visible FH

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40
Q

when to repeat hCG if conservative management of tubal ectopic

A

D2, 4 and 7 needs to drop by at least 15%

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41
Q

criteria for medical management of tubal ectopic

A

1) hCG 1500-5000 2) no visible FH 3) no IUP 4) <35mm

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42
Q

when to repeat hCG if medical management of tubal ectopic

A

days 4 and 7

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43
Q

medical or conservative tubal ectopic management, hCG monitoring

A

if decreasing by >15%, repeat weekly until negative. if increasing or <15%, needs USS +/- repeat dose

44
Q

MTX for tubal ectopic - how long to wait before next conception attempt

A

3/12

45
Q

hCG monitoring for salpingotomy

A

day 7 then weekly

46
Q

risk of persistent trophoblast with salpingotomy

A

7% (vs 1%)

47
Q

risk of repeat ectopic after salpingotomy

A

8% (vs 5%)

48
Q

risk of requiring further treatment after salpingotomy

A

1/5

49
Q

what percentage of medical management ectopic will need second dose of MTX

A

3-27%

50
Q

incidence of cervical ectopic

A

<1%

51
Q

cervical ectopic USS features

A

empty uterine cavity, barrel shaped cx, gestational sac below internal os, absence of sliding sign, blood flow around sac

52
Q

incidence of c-scar ectopic

A

1/2000 (13% misdiagnosed as IUP or cervical)

53
Q

c-scar ectopic USS features

A

empty uterine cavity, GS or trophoblast anteriorly at level of internal os, embedded at site of previous scar, thin or absent layer of myometrium, doppler +, empty endocervical canal

54
Q

incidence of interstital ectopic pregnancy

A

1-6%

55
Q

interstitial pregnancy USS features

A

empty uterine cavity, POC or GS laterally in interstitial part of tube, <5mm myometrium, interstitial line sign

56
Q

surgical options of interstitial pregnancy

A

electrocauterization, wedge resection or salpingotomy, hysteroscopic resection UAE + MTX

57
Q

incidence of cornual pregnancy

A

1/7600 (rarest)

58
Q

abx prophylaxis prior to STOP

A

200mg doxycycline PO stat

59
Q

medical abortion dose <10/40

A

interval treatment mife/miso 24-48h (200mg mife + 800mcg miso)

60
Q

medical abortion dose 10-24/40

A

200mg mife, + 800mcg miso PV, then 400mcg q3h

61
Q

medical abortion dose 24-25/40

A

200mg mife, + 400mcg miso q3h

62
Q

medical abortion dose 25-28/40

A

200mg mife, + 200mg miso q4h

63
Q

medical abortion dose >38/40

A

200mg mife, + 100mcg miso q6h

64
Q

incidence of N/V in pregnancy

A

up to 80%

65
Q

incidence of HG

A

0.3-3.6%

66
Q

TFT abnormal in ___% of HG

A

66% (check for TSH receptor antibodies)

67
Q

what % of women will need time off work due to N/V in pregnancy

A

30%

68
Q

when does HG usually resolve by

A

90% resolve by 20 weeks

69
Q

common electrolyte abnormality in HG

A

hypokalemia, hyponatremia, decreased urea, increased creatinine

70
Q

LFT abnormal in ___% of HG cases

A

40%

71
Q

acid-base disturbance in HG

A

metabolic hypochloremic alkalosis

72
Q

first line fluid replacement for HG

A

NaCL/KCl

73
Q

first line antiemetics for HG

A

cyclizine, prochlorperazine, promethazine, chlorpromazine

74
Q

second line antiemetics for HG

A

metaclopramide, domperidone, ondansetron

75
Q

third line antiemetics for HG

A

corticosteroids (hydrocortisone 100mg IV BD, taper done to prednisolone 40-50mg PO)

76
Q

PUQE score mild

A

<6

77
Q

PUQE score moderate

A

7-12

78
Q

PUQE score severe

A

13-15

79
Q

incidence of complete molar

A

1/1000

80
Q

most common karyotype complete molar

A

46XX (90%)

81
Q

most common karyotype partial molar

A

69XXY (70%) triple X next most common

82
Q

% of partial molar that is tetraploid or mosaic

A

10%

83
Q

incidence of partial mole

A

3/1000

84
Q

tumour marker expressed in partial mole

A

p57

85
Q

follow-up for complete molar pregnancy

A

if hCG reverts back to normal within 56 days of pregnancy, then 6 months from date of evac; otherwise 6 months from normalization

86
Q

follow-up for partial molar pregnancy

A

concluded once hCG has returned to normal on two samples, at least 4 weeks apart

87
Q

how long to wait prior to conception after chemo for GTN

A

1 year after completion of treatment

88
Q

% of women with GTN who achieve pregnancy

A

80%

89
Q

incidence of choriocarcinoma after molar pregnancy

A

1/40 (3%)

90
Q

when is emergency contraception required

A

from D21 postpartum, from D5 post TOP/SMM, if regular contraception compromised

91
Q

EC for failed hormonal contraception: patch or ring

A

UPSI in week 1 or >58h HFI

92
Q

EC: >9 completed days since last active pill was taken

A

consider EC if UPSI has taken place during or after HFI; take the most recent missed pill as soon as possible; condoms should be used or sex avoided until pill taken for 7 consecutive days; consider f/u pregnancy test

93
Q

EC: 1 pill missed in week 1 after HFI

A

EC not required. take missed pill ASAP and continue remaining pills at usual time. No additional contraception required if correct use in week 1 and prior to HFI.

94
Q

EC: 1 pill missed in week 2 or 3

A

EC not required. take missed pill ASAP and continue remaining pills at usual time. No additional contraception required if correct use in previous 7 days.

95
Q

EC: 2-7 missed pills in week 1 after HFI

A

consider EC if UPSI during HFI or week1. Take most recent missed pill ASAP and continue remaining pills at usual time. Use condoms or sex avoided until pills have been taken for 7 consecutive days. Consider f/u pregnancy test.

96
Q

EC: 2-7 missed pills in week 2 or 3 after HFI

A

EC not required if consistent correct use in previous 7 days. If >2 pills missed in 7 days prior to HFI, omit HFI. Condoms should be used or sex avoided until pills have been taken for 7 consecutive days.

97
Q

EC: >7 consecutive pills missed in any week of pill taking

A

Consider EC. Manage as new start contraception. consider immediate pregnancy test. use condoms for 7 days.

98
Q

EC: late or missed POP

A

(>27h traditional, >36h DSG) if UPSI or barrier failure before efficacy has been re-established (ie 48h after restarting). Missed pill should be taken ASAP (only 1 missed pill if more than 1 missed). Next pill should be taken at usual time. Additional contraception for 2 days.

99
Q

EC: DMPA

A

late injection >14 weeks after last or within 7 days after late injection.

100
Q

background VTE risk

A

2/10 000

101
Q

pregnancy VTE risk

A

1-2/1000

102
Q

levonorgestrel, norgestimate, morethisterone VTE risk

A

5-7/10 000

103
Q

gestogene, desogestrol, drospirinone VTE risk

A

9-12/10 000

104
Q

most common bacterial STI

A

chlamydia also most common cause of preventable infertility

105
Q

EC-IUD, abx choice if risk of chlamydia

A

doxycyline 100mg BD x 7/7 if wishes to avoid risk of teratogenicity, azithromycin 1g stat + 500mg daily for 2 days.

106
Q

EC IUD, abx risk of gonorrhea infection

A

ceftriaxone 1g IM stat