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Unit 5: Path - The Femal Reproductive System, the Peritoneum, and Pregnancy > Squamous Cell Neoplasia > Flashcards

Squamous Cell Neoplasia Flashcards

1
Q

What is Cervical Intraepithelial Neoplasia a precursor of?

A

Invasive squamous cell carcinoma

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2
Q

What is the critical factor that can lead to cervical cancer?

A

HPV infection

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3
Q

What is the cellular morphology that is used to identify cells with HPV infection?

A

Koilocytes

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4
Q

What proteins are endoded by HPV and what proteins do these proteins inhibit?

A

E6/E7 proteins that bind and inactivate p53 and Rb

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5
Q

What two types of HPV are found in 70% of invasive cancers?

A

HPV 16 and 18

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6
Q

What determines the distribution of cervical intraepithelial neoplasia and cervical cancer?

A

The transformation zone on the exposed portion of the cervix

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7
Q

What is CIN-1?

A

Mild dysplasia

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8
Q

What is CIN-2?

A

Moderate dysplasia

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9
Q

What is CIN-3?

A

Severe dysplasia

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10
Q

What is the earliest stage of Invasive Cervical Cancer?

A

Microinvasive Squamous Cell Carcinoma

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11
Q

What is the most common type of cervical cancer?

A

Squamous Cell Carcinoma

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12
Q

What is the most common means of spread of cervical cancer?

A

Direct extension thru the lymphatic vessels

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13
Q

What is the grade of of the following cervical intraepithelial neoplasia? Typical characteristics?

A

CIN-1; Pronounced cellular atypia in the basal third

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14
Q

What is the grade of cervical intraepithelial neoplasia? Typical characteristics?

A

CIN-2; Pronounced cellular atypia in basal third

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15
Q

What is the grade of cervical intraepithelial neoplasia? Typical characteristics?

A

CIN-3; Neoplastic cells are present thruout the entire epithelium

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16
Q

What is a characteristic associated with cervical dysplasia?

A

Cervical mosaicism

17
Q

What is another name for cervical adenocarcinoma in situ?

A

Cervical glandular intraepithelial neoplasia

Unit 5: Path - The Femal Reproductive System, the Peritoneum, and Pregnancy (25 decks)

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