Malignant and Premalignant Tumors of the Vulva

Question 1

What is a precursor of Invasive Squamous Cell Carcinoma in the vulva?

Answer 1

Vulvar Intraepithelial Neoplasia

Question 2

What are the two types of vulvar intraepithelial neoplasia?

Answer 2

Well-differentiated (simplex) type and HPV-related undifferentiated (classic)

Question 3

Which type of Vulvar intraepithelial neoplasia is more common?

Answer 3

Well-differentiated simplex type

Question 4

What type of HPV is the typical cause of undifferentiated vulvar intraepithelial neoplasia?

Answer 4

HPV 16

Question 5

What is Bowen disease?

Answer 5

Synonym for VIN III

Question 6

From what VIN does SCC typically follow?

Answer 6

Differentiated VIN

Question 7

What Syx is observed in SCC but not VIN?

Answer 7

Ulceration, bleeding, secondary infection

Question 8

What determines Px of SCC?

Answer 8

Stage of disease and lymph node status

Question 9

What causative agent is typically ID’ed in Verrucous Carcinoma?

Answer 9

Either HPV 6 or 11

Question 10

What is the Dx? What is the uscopic Dx cell of this disease? What is the Px?

Answer 10

Paget Disease; Paget Cell; Good Px, Tx requires only excision