Spleen

Question 1

Secondary immune organ located in LUQ of abdomen

Answer 1

Spleen

Question 2

Secondary immune organ located anterior to the left kidney

Answer 2

Spleen

Question 3

Secondary immune organ protected by 9th-11th ribs

Answer 3

Spleen

Question 4

Structure located in red pulp of spleen with long vascular channels and fenestrated “barrel hoop” basement membrane?

Answer 4

Sinusoids

Question 5

Cells found in the periarteriolar lymphoid sheath (PALS) within the white pulp of spleen

Answer 5

T cells

Question 6

Cells found in follicles within the white pulp of spleen

Answer 6

B cells

Question 7

Zone located between the red pulp and white pulp of spleen

Answer 7

Marginal zone

Question 8

Cells found in the marginal zone

Answer 8

Macrophages and specialized B cells

Question 9

Area of spleen where APC’s capture blood-borne antigens for recognition by lymphocytes

Answer 9

Marginal zone

Question 10

Macrophages found nearby in spleen remove…

Answer 10

encapsulated bacteria

Question 11

Patients undergoing splenectomy should…

Answer 11

be vaccinated against encapsulated organisms (pneumococcal, Hib, meningococcal)

Question 12

Cells found in the white pulp of the spleen

Answer 12

WBCs

Question 13

Examples of splenic dysfunction include…

Answer 13

postsplenectomy and sickle cell disease

Question 14

Splenic dysfunction leads to…

Answer 14

(1) decreased IgM, (2) decreased complement activation, (3) decreased C3b, (4) increased susceptibility to encapsulated organisms