Grafts and Transplant rejection Flashcards
Autograft donor
Self
Syngeneic draft donor
Identical twin or clone
Allograft donor
Nonidentical individual of same species
Xenograft donor
Different species
Hyperacute rejection onset
Within minutes
Treatment for hyperacute rejection
Remove graft
Pre-existing recipient antibodies react to donor antigen and activate complement is seen in what type of transplant rejection
Hyperacute
Hyperacute rejection is what type of hypersensitivity reaction
Type II
Widespread thrombosis of graft vessels leading to ischemia and necrosis is seen in what type of transplant rejection
Hyperacute
Acute rejection onset
Weeks to months
Cellular response in acute rejection with mechanism
CD8+ T-cells activated against donor MHCI
Type of hypersensitivity reaction in acute rejection involving a cellular response
Type IV
Humoral response in acute rejection with mechanism
Antibodies develop after organ transplant and react to donor antigen
Treatment for acute transplant rejection
Prevent/revers with immunosuppressants
Vasculitis of graft vessels with dense interstitial lymphocytic infiltrate is seen in what type of transplant rejection
Acute
What type of infiltrates are seen in acute transplant rejection
Lymphocytic infiltrate
Chronic transplant rejection onset
Months to years
What cells are involved in chronic transplant rejection
CD4+ T cells and APCs
Mechanism of chronic transplant rejection
CD4+ T-cells respond to recipient APCs presenting donor peptides, including allogeneic MHC
Broncholitis obliterans is seen in what type of transplant rejection
Chronic
Accelerated atherosclerosis is seen in what type of transplant rejection
Chronic
Chronic graft nephropathy is seen in what type of transplant rejection
Chronic
Vanishing bile duct syndrome is seen in what type of transplant rejection
Chronic
Chronic transplant rejection involves what type of hypersensitivity reaction
Bothe type II and type IV (cellular and humoral components)
Recipeint T cells reacting and secreting cytokines leading to proliferation of vascular smooth muscle, parenchymal atrophy, interstitial fibrosis is seen in what type of transplant rejection
Chronic
Transplant patient presents with maculopapular ras, jaundice and hepatosplenomegaly has what type of rejection
Graft-vs-host disease
Onset of Graft-vs-host disease
Varies
Graft-vs-host disease is what type of hypersensitivity reaction
Type IV
Mechanism of graft-vs-host disease
Grafted immunocompetent T-cells proliferate in immunocompromised host and reject host cells with foreign proteins
Outcome of graft-vs-host disease when grafted immunocompromised T-cells proliferate and reject host cells with foreign proteins
Severe organ dysfunction
